(Q43567640)

24 November 2017

Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies (English)

1 reference

24 November 2017

R R Streiff

1

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PubMed ID

11291831

24 November 2017

J F Bender

series ordinal

2

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24 November 2017

1 January 2001

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Investigational New Drugs

24 November 2017

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24 November 2017

19

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24 November 2017

1

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24 November 2017

29-39

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https://scigraph.springernature.com/pub.10.1023/a:1006448516938

24 November 2017

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cites work

Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines

1 reference

12 December 2020

Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action

1 reference

12 December 2020

In vivo interaction of a polyamine with the NMDA receptor

1 reference

12 December 2020

Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation.

1 reference

12 December 2020

Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues

1 reference

12 December 2020

Polyamine-enhanced NMDA receptor activity: effect of ethanol

1 reference

12 December 2020

In vivo pharmacological study of spermine-induced neurotoxicity

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12 December 2020

Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.

1 reference

12 December 2020

Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine

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12 December 2020

Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells

1 reference

12 December 2020

Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models

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12 December 2020

Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts

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12 December 2020

Ornithine decarboxylase as a biologic marker in familial colonic polyposis

1 reference

12 December 2020

Regulation of polyamine transport by polyamines and polyamine analogs

1 reference

12 December 2020

Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy.

1 reference

12 December 2020

Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.

1 reference

12 December 2020

Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells

1 reference

12 December 2020

Antiproliferative properties of polyamine analogues: a structure-activity study

1 reference

12 December 2020

Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues

1 reference

12 December 2020

Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines

1 reference

12 December 2020

The gastrointestinal tract as polyamine source for tumor growth

1 reference

12 December 2020

Regulation of polyamine transport in Chinese hamster ovary cells

1 reference

12 December 2020

Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.

1 reference

12 December 2020

Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells

1 reference

12 December 2020

Differential effects of the spermine analog, N1, N12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes

1 reference

12 December 2020

Microbial flora in the gastrointestinal tract abolishes cytostatic effects of alpha-difluoromethylornithine in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1006448516938

1 reference

PubMed ID

11291831

Dimensions Publication ID

24 November 2017

0 references

1 reference

PubMed ID

11291831