(Q43580950)

24 November 2017

Using model-system genetics for drug-based target discovery (English)

1 reference

24 November 2017

D J. Matthews

1

1 reference

PubMed ID

11165187

24 November 2017

J Kopczynski

series ordinal

2

1 reference

24 November 2017

1 February 2001

1 reference

24 November 2017

1 reference

24 November 2017

6

1 reference

24 November 2017

141-149

1 reference

24 November 2017

3

1 reference

Drug discovery: a historical perspective

24 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The Ras signaling pathway in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Genetics of RAS signaling in C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Resistance to HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: theory and practice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Comparative genomics of the eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Mechanisms of action and clinical characteristics of three atypical antidepressants: venlafaxine, nefazodone, bupropion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Strategies for discovering drugs from previously unexplored natural products

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Phorboxazoles A and B: potent cytostatic macrolides from marine sponge Phorbas species

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Targeted selection of recombinant clones through gene dosage effects

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Functional discovery via a compendium of expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Cluster analysis and display of genome-wide expression patterns

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Knowledge-based analysis of microarray gene expression data by using support vector machines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Analysis of large-scale gene expression data

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The trace amine tyramine is essential for sensitization to cocaine in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Requirement of circadian genes for cocaine sensitization in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The identification of myriocin-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Inhibition of protein synthesis by didemnin B: how EF-1alpha mediates inhibition of translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Structure of human methionine aminopeptidase-2 complexed with fumagillin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Peptide sequencing by mass spectrometry for homology searches and cloning of genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Advances in surface plasmon resonance biosensor analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Biomedical discovery with DNA arrays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Gene expression analysis by transcript profiling coupled to a gene database query

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Proteomics to study genes and genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2901612-3

7 January 2021

10.1016/S1359-6446(00)01612-3

Identifiers

DOI

1 reference

24 November 2017

1 reference

PubMed ID

11165187