(Q43597902)

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Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

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7 November 2019

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop (English)

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7 November 2019

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7 November 2019

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7 November 2019

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Zhang F

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7 November 2019

Romano PR

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7 November 2019

Nagamura-Inoue T

3

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7 November 2019

Mathews MB

6

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7 November 2019

Ozato K

7

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7 November 2019

Hinnebusch AG

8

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7 November 2019

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3 May 2001

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7 November 2019

Journal of Biological Chemistry

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7 November 2019

276

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7 November 2019

24946-24958

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7 November 2019

27

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7 November 2019

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Proteins binding to duplexed RNA: one motif, multiple functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

RNA recognition by a Staufen double-stranded RNA-binding domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Crystal structure of cyclin-dependent kinase 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Active and inactive protein kinases: structural basis for regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102108200

21 January 2018

Identifiers

10.1074/JBC.M102108200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11337501%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11337501%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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