(Q43597906)

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Identification of active site residues in glucosylceramide synthase. A nucleotide-binding catalytic motif conserved with processive beta-glycosyltransferases

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scholarly article

1 reference

Europe PubMed Central

25 November 2017

Identification of active site residues in glucosylceramide synthase. A nucleotide-binding catalytic motif conserved with processive beta-glycosyltransferases (English)

1 reference

Europe PubMed Central

25 November 2017

author name string

Marks DL

1

1 reference

Europe PubMed Central

25 November 2017

Dominguez M

2

1 reference

Europe PubMed Central

25 November 2017

Wu K

3

1 reference

Europe PubMed Central

25 November 2017

Pagano RE

4

1 reference

Europe PubMed Central

25 November 2017

language of work or name

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publication date

3 May 2001

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Europe PubMed Central

25 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

25 November 2017

276

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Europe PubMed Central

25 November 2017

28

1 reference

Europe PubMed Central

25 November 2017

26492-26498

1 reference

Europe PubMed Central

25 November 2017

Chemotherapy by slowing glucosphingolipid synthesis

1 reference

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New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules,involved in cell adhesion coupled with signaling.

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21 January 2018

Stemming the tide: glycosphingolipid synthesis inhibitors as therapy for storage diseases

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Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation

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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

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Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

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Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase

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Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.

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21 January 2018

Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin

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Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.

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21 January 2018

Glucosylceramide synthase and glycosphingolipid synthesis

1 reference

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21 January 2018

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

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21 January 2018

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21 January 2018

Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase

1 reference

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21 January 2018

Topology of glucosylceramide synthesis in Golgi membranes from porcine submaxillary glands.

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21 January 2018

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions

1 reference

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21 January 2018

Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver

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21 January 2018

Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes

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21 January 2018

Methods for studying glucosylceramide synthase

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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Identification of common molecular subsequences

1 reference

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Improved tools for biological sequence comparison

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21 January 2018

Multidomain architecture of beta-glycosyl transferases: implications for mechanism of action

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21 January 2018

The cellulose synthase gene of Dictyostelium

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A novel pathway for O-polysaccharide biosynthesis in Salmonella enterica serovar Borreze.

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Detection of two loci involved in (1-->3)-beta-glucan (curdlan) biosynthesis by Agrobacterium sp. ATCC31749, and comparative sequence analysis of the putative curdlan synthase gene.

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21 January 2018

Conserved domains of glycosyltransferases

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Higher plants contain homologs of the bacterial celA genes encoding the catalytic subunit of cellulose synthase

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X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily

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21 January 2018

Glycosyltransferase structure and mechanism

1 reference

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The 1.9 Å crystal structure ofEscherichia coliMurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis

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21 January 2018

Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms

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21 January 2018

Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose

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21 January 2018

CELLULOSE BIOSYNTHESIS: Exciting Times for A Difficult Field of Study

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21 January 2018

Molecular cloning and characterization of a putative mouse hyaluronan synthase

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21 January 2018

The C-terminal domain of the Rhizobium leguminosarum chitin synthase NodC is important for function and determines the orientation of the N-terminal region in the inner membrane.

1 reference

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21 January 2018

A single gene (tts) located outside the cap locus directs the formation of Streptococcus pneumoniae type 37 capsular polysaccharide. Type 37 pneumococci are natural, genetically binary strains.

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Improved Inhibitors of Glucosylceramide Synthase

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Cancer-associated glycosphingolipid antigens: their structure, organization, and function

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Inhibition of Glycosphingolipid Biosynthesis: Application to Lysosomal Storage Disorders

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21 January 2018

N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo

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Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study

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Characterization of chitin synthase 2 of Saccharomyces cerevisiae. Implication of two highly conserved domains as possible catalytic sites

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Identifiers

10.1074/JBC.M102612200

1 reference

Europe PubMed Central

25 November 2017

1 reference

Europe PubMed Central

25 November 2017

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