(Q43660559)

25 November 2017

title

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase (English)

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25 November 2017

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4

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25 November 2017

Montalvetti A

1

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25 November 2017

Bailey BN

2

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25 November 2017

Martin MB

3

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25 November 2017

Oldfield E

5

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25 November 2017

Docampo R

6

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25 November 2017

language of work or name

English

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publication date

2 July 2001

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Journal of Biological Chemistry

25 November 2017

published in

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25 November 2017

volume

276

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25 November 2017

issue

36

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25 November 2017

page(s)

33930-33937

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

25 November 2017

cites work

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Developments in the therapeutic applications of bisphosphonates

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Therapeutic approaches to bone diseases

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Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

21 January 2018

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Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

21 January 2018

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The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

21 January 2018

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Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

21 January 2018

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Acidocalcisome: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites

21 January 2018

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The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

21 January 2018

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Molecular analysis of prenyl chain elongating enzymes

21 January 2018

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Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

21 January 2018

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A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.

21 January 2018

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Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi.

21 January 2018

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Cloning and expression of Trypanosoma cruzi ribosomal protein P0 and epitope analysis of anti-P0 autoantibodies in Chagas' disease patients

21 January 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

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The graphical determination of Km and Ki

21 January 2018

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Regulation of product chain length by isoprenyl diphosphate synthases

21 January 2018

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Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II

21 January 2018

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Targeting proteins to the glycosomes of African trypanosomes

21 January 2018

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Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase

21 January 2018

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21 January 2018

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Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli

21 January 2018

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Affinity-tagged miniprion derivatives spontaneously adopt protease-resistant conformations

21 January 2018

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Farnesyl pyrophosphate synthase from white lupin: molecular cloning, expression, and purification of the expressed protein

21 January 2018

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LEFPS1, a tomato farnesyl pyrophosphate gene highly expressed during early fruit development

21 January 2018

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Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

21 January 2018

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Essential role for mevalonate synthesis in DNA replication

21 January 2018

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Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate

21 January 2018

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Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei.

21 January 2018

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Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.

21 January 2018

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

21 January 2018

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Programmed cell death in trypanosomatids.

21 January 2018

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Isotopes incorporated in the Nucleic Acids of Trypanosoma mega

21 January 2018

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Sterol biosynthesis inhibitors: potential chemotherapeutics against Chagas disease

21 January 2018

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Mechanisms of action of bisphosphonates

21 January 2018

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Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

21 January 2018

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Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway

21 January 2018

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Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

21 January 2018

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Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase

21 January 2018

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Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M103950200

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25 November 2017

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