(Q43670289)

25 November 2017

title

Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity (English)

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25 November 2017

Yong-Ning Xin

1

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25 November 2017

Yuqi Zhao

2

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25 November 2017

Zhong-Hua Lin

3

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25 November 2017

Xiangjun Jiang

4

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25 November 2017

Shi-Ying Xuan

5

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25 November 2017

Jingfei Huang

6

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25 November 2017

language of work or name

English

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publication date

5 November 2012

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25 November 2017

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25 November 2017

volume

81

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25 November 2017

issue

3

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25 November 2017

page(s)

406-414

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Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

25 November 2017

cites work

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Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage

21 January 2018

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A feed-forward loop amplifies nutritional regulation of PNPLA3

21 January 2018

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

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Genetic variance in the adiponutrin gene family and childhood obesity.

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Variant in PNPLA3 is associated with alcoholic liver disease

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A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

21 January 2018

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A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

21 January 2018

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Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

21 January 2018

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Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

21 January 2018

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A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

21 January 2018

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A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans

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21 January 2018

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Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

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21 January 2018

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21 January 2018

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The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

21 January 2018

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Stereochemistry of polypeptide chain configurations

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Scalable molecular dynamics with NAMD

21 January 2018

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

21 January 2018

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Importance of the CMAP correction to the CHARMM22 protein force field: dynamics of hen lysozyme

21 January 2018

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21 January 2018

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21 January 2018

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Contribution of conformer focusing to the uncertainty in predicting free energies for protein-ligand binding.

21 January 2018

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Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

21 January 2018

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Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PROT.24199

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25 November 2017

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