(Q43689095)

25 November 2017

A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage (English)

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25 November 2017

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C C Lee

1

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PubMed ID

11474790

25 November 2017

T S Huang

series ordinal

2

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PubMed ID

11474790

25 November 2017

language of work or name

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1 June 2001

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25 November 2017

6

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inferred from page(s)

published in

Pharmaceutical Research

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25 November 2017

18

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25 November 2017

6

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25 November 2017

846-851

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Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants

25 November 2017

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12 December 2020

Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide

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12 December 2020

DNA topoisomerases in cancer therapy.

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12 December 2020

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage

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12 December 2020

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

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12 December 2020

DNA topoisomerase II cleavage of telomeres in vitro and in vivo

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12 December 2020

A consensus sequence for cleavage by vertebrate DNA topoisomerase II.

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12 December 2020

Telomere length regulation

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12 December 2020

Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

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12 December 2020

A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells.

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12 December 2020

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

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12 December 2020

Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats

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12 December 2020

Antiproliferative activity of G-rich oligonucleotides correlates with protein binding

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12 December 2020

In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents

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12 December 2020

Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements

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12 December 2020

Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

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12 December 2020

Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative

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12 December 2020

Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II

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12 December 2020

DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells

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12 December 2020

Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.

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12 December 2020

Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening

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12 December 2020

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

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12 December 2020

Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity.

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12 December 2020

Identifiers

DOI

10.1023/A:1011048831698

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25 November 2017

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PubMed ID

11474790