(Q43701636)

English

Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure.

scientific article published on 8 August 2001

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scholarly article

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10 November 2019

Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure (English)

1 reference

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10 November 2019

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10 November 2019

author name string

Marie J

1

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10 November 2019

Pruneau D

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10 November 2019

Paquet JL

4

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10 November 2019

Siatka C

5

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10 November 2019

Larguier R

6

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10 November 2019

Poncé C

7

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10 November 2019

Vassault P

8

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10 November 2019

Groblewski T

9

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10 November 2019

Maigret B

10

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10 November 2019

Bonnafous JC

11

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10 November 2019

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8 August 2001

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10 November 2019

Journal of Biological Chemistry

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10 November 2019

276

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10 November 2019

44

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10 November 2019

41100-41111

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10 November 2019

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis.

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Identification of a ligand-dependent switch within a muscarinic receptor

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Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

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LF 16.0335, a novel potent and selective nonpeptide antagonist of the human bradykinin B2 receptor

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Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist

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An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

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Crystal structure of rhodopsin: A G protein-coupled receptor

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21 January 2018

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

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Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation

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21 January 2018

Mutations in the B2 bradykinin receptor reveal a different pattern of contacts for peptidic agonists and peptidic antagonists

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Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

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Dependence of AT1 angiotensin receptor function on adjacent asparagine residues in the seventh transmembrane helix.

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21 January 2018

The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains

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G-Protein coupled receptors: models, mutagenesis, and drug design.

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The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

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Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.

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Single amino acid residue as a functional determinant of rod and cone visual pigments

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Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin

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Structural alterations for proton translocation in the M state of wild-type bacteriorhodopsin

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Molecular mechanism of vectorial proton translocation by bacteriorhodopsin

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Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin

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Role of the C9 methyl group in rhodopsin activation: characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal.

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G protein-coupled receptors. II. Mechanism of agonist activation.

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Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

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Role of aromatic transmembrane residues of the delta-opioid receptor in ligand recognition

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21 January 2018

Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding

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Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants

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Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor

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Polar group burial contributes more to protein stability than nonpolar group burial

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Phe310 in transmembrane VI of the alpha1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

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Amino acids of the third transmembrane domain of the AT1A angiotensin II receptor are involved in the differential recognition of peptide and nonpeptide ligands

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Functional Microdomains in G-protein-coupled Receptors

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Constitutive activation of the human bradykinin B2 receptor induced by mutations in transmembrane helices III and VI.

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Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin

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A computer modeling postulated mechanism for angiotensin II receptor activation

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Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms

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The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

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Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor

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A single position in the third transmembrane domains of the human B1 and B2 bradykinin receptors is adjacent to and discriminates between the C-terminal residues of subtype-selective ligands

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Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor

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A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation.

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Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor

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Movement of retinal along the visual transduction path

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Spectroscopic evidence for interaction between transmembrane helices 3 and 5 in rhodopsin

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The hydrogen-bonding network of water molecules and the peptide backbone in the region connecting Asp83, Gly120, and Glu113 in bovine rhodopsin

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Relocation of internal bound water in bacteriorhodopsin during the photoreaction of M at low temperatures: an FTIR study

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Protein conformational changes in the bacteriorhodopsin photocycle

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The molecular origin of the inhibition of transducin activation in rhodopsin lacking the 9-methyl group of the retinal chromophore: a UV-Vis and FTIR spectroscopic study

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Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

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Asparagine-mediated self-association of a model transmembrane helix

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Interhelical hydrogen bonding drives strong interactions in membrane proteins

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Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function

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Identification of residues involved in ligand binding to the neurokinin-2 receptor

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Identifiers

10.1074/JBC.M104875200

1 reference

Europe PubMed Central

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10 November 2019

1 reference

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10 November 2019

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