(Q43736634)

English

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

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Europe PubMed Central

PubMed publication ID

26 November 2017

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

author name string

Boger DL

1

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Johnson DS

2

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Yun W

3

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Tarby CM

4

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

language of work or name

0 references

publication date

1 February 1994

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

26 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

115-135

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

Duocarmycin A, a new antitumor antibiotic from Streptomyces.

1 reference

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Structures of duocarmycins, novel antitumor antibiotics produced by Streptomyces sp.

1 reference

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7 January 2021

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DC89-A1, a new antitumor antibiotic from Streptomyces

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

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New antitumor antibiotics, duocarmycins B1 and B2.

1 reference

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Pyrindamycins A and B, new antitumor antibiotics

1 reference

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7 January 2021

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Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence selectivity of DNA covalent modification

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

1 reference

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7 January 2021

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Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Antitumor activity and biochemistry of novel analogs of the antibiotic, CC-1065

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis for sequence-specific DNA alkylation by CC-1065

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversibility of the covalent reaction of CC-1065 and analogues with DNA

1 reference

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7 January 2021

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Two-dimensional 1H and 31P NMR spectra and restrained molecular dynamics structure of a covalent CPI-CDPI2-oligodeoxyribonucleotide decamer complex

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

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DNA interstrand cross-links induced by the cyclopropylpyrroloindole antitumor agent bizelesin are reversible upon exposure to alkali

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982007-6

7 January 2021

based on heuristic

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Concerted DNA recognition and novel site-specific alkylation by duocarmycin A with distamycin A.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0968-0896(00)82007-6

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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