(Q43762910)

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Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

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12 November 2019

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity (English)

1 reference

Europe PubMed Central

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12 November 2019

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Michael J. Rogers

7

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12 November 2019

author name string

S Suri

1

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12 November 2019

J Mönkkönen

2

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12 November 2019

M Taskinen

3

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12 November 2019

J Pesonen

4

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12 November 2019

M A Blank

5

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12 November 2019

R J Phipps

6

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12 November 2019

publication date

1 October 2001

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12 November 2019

1 reference

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12 November 2019

29

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12 November 2019

4

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12 November 2019

336-343

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12 November 2019

Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells

1 reference

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7 January 2021

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Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonclinical model for assessing gastric effects of bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Esophagitis associated with the use of alendronate

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Alendronate induces gastric injury and delays ulcer healing in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis in caco-2 cells by wheat gliadin peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Excess gastric ulcers are associated with alendronate therapy

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Alendronate gastric ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of bisphosphonates on surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pamidronate: an unrecognized problem in gastrointestinal tolerability

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative study of potential for bisphosphonates to damage gastric mucosa of rats

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis and gastrointestinal pharmacology.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates: from the laboratory to the clinic and back again

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytotoxicity of absorption enhancers in Caco-2 cell monolayers.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytotoxic effects of pamidronate on monolayers of human intestinal epithelial (Caco-2) cells and its epithelial transport

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The effects of nitrogen-containing bisphosphonates on human epithelial (Caco-2) cells, an in vitro model for intestinal epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Upper gastrointestinal adverse events and cyclical etidronate.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

N-bisphosphonates cause gastric epithelial injury independent of effects on the microcirculation

1 reference

https://api.crossref.org/works/10.1016%2FS8756-3282%2801%2900589-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell death: the significance of apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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