(Q43835040)

English

Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide

scientific article published in June 2001

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

author name string

Reddy S

1

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Young M

2

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Ginn S

3

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

publication date

1 June 2001

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Journal of Molecular Histology

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

317-327

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese diabetic (NOD) mice during disease acceleration with cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinamide inhibits enhanced in vitro production of interleukin-12 and tumour necrosis factor-alpha in peripheral whole blood of people at high risk of developing type 1 diabetes and people with newly diagnosed type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal relationship between immune cell influx and the expression of inducible nitric oxide synthase, interleukin-4 and interferon-gamma in pancreatic islets of NOD mice following adoptive transfer of diabetic spleen cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual-label immunohistochemical study of interleukin-4-and interferon-gamma-expressing cells within the pancreas of the NOD mouse during disease acceleration with cyclophosphamide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of cyclophosphamide-induced accelerated diabetes in the NOD mouse by nicotinamide or a soy protein-based infant formula

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor α is prevented by inhibitors of poly(ADP-ribose) polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-βModulates the Acute Release of Growth Hormone-Releasing Hormone and Somatostatin from Rat Hypothalamusin Vitro, Whereas Tumor Necrosis Factor and Interleukin-6 Have No Effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of poly (ADP-ribose) polymerase suppress lipopolysaccharide-induced nitrite formation in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 and interleukin-1 antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-secreting beta-cells possess specific receptors for interleukin-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential contribution of macrophages to islet cell destruction in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early nicotinamide treatment in the NOD mouse: effects on diabetes and insulitis suppression and autoantibody levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactive interleukin-1 beta localization in the rat forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for IL-6 production by and effects on the pancreatic beta-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type I diabetes mellitus. A chronic autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines cause functional and structural damage to isolated islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of mRNA contents of interleukin-1 beta and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon expression in the pancreases of patients with type I diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analyses of pancreatic macrophages and CD4 and CD8 T cell subsets prior to and following diabetes in the NOD mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-dependent diabetes mellitus as an autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta-cell-selective production of tumor necrosis factor-alpha induced by interleukin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinamide--biological actions and therapeutic potential in diabetes prevention. IDIG Workshop, Copenhagen, Denmark, 4-5 December 1992.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of interleukin-1 in the pathogenesis of IDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from nicotinamide inhibition of interleukin-1 beta-induced RIN cell nitric oxide formation is associated with induction of MnSOD enzyme activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse islet cell lysis mediated by interleukin-1-induced Fas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant TCR alpha-chain clonotypes and interferon-gamma are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monokine-producing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of insulin-dependent diabetes mellitus 1998

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 produced and released endogenously within human islets inhibits beta cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/11758808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1012422821187

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

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