(Q43844173)

27 November 2017

title

Comparable DNA and chromosome damage in Chinese hamster ovary cells by chlorohydroxyfuranones (English)

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27 November 2017

Mäki-Paakkanen J

1

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27 November 2017

Laaksonen M

2

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27 November 2017

Munter T

3

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27 November 2017

Kronberg L

4

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27 November 2017

Komulainen H

5

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27 November 2017

language of work or name

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1 January 2001

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Environmental and Molecular Mutagenesis

27 November 2017

published in

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27 November 2017

volume

38

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27 November 2017

issue

4

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27 November 2017

page(s)

297-305

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Genotoxic effects of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in mammalian cells in vitro and in rats in vivo

27 November 2017

cites work

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DNA strand breaks induced in cultured human and rodent cells by chlorohydroxyfuranones—mutagens isolated from drinking water

21 January 2018

1 reference

Induction of gastrointestinal tract nuclear anomalies in B6C3F1 mice by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone and 3,4-(dichloro)-5-hydroxy-2[5H]-furanone, mutagenic byproducts of chlorine disinfection

21 January 2018

1 reference

Mutation spectra in salmonella of chlorinated, chloraminated, or ozonated drinking water extracts: comparison to MX.

21 January 2018

1 reference

Mutation spectra in Salmonella of analogues of MX: implications of chemical structure for mutational mechanisms.

21 January 2018

1 reference

Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104.

21 January 2018

1 reference

Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells

21 January 2018

1 reference

DNA damage induced by the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in mammalian cells in vitro and in mice

21 January 2018

1 reference

PM2 DNA damage induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX).

21 January 2018

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Lack of uniformity in the mutational spectra of chlorohydroxyfuranones in Salmonella typhimurium strain TA100.

21 January 2018

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Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells.

21 January 2018

1 reference

Induction of gene mutation in mammalian cells by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinfection by-product in drinking water

21 January 2018

1 reference

Cytogenetic effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in rat peripheral lymphocytes in vitro and in vivo

21 January 2018

1 reference

Mutagenicity in vitro of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid), a chlorine disinfection by-product in drinking water

21 January 2018

1 reference

Mutational spectra of Salmonella typhimurium revertants induced by chlorohydroxyfuranones, byproducts of chlorine disinfection of drinking water.

21 January 2018

1 reference

Drinking water mutagenicity and leukemia, lymphomas, and cancers of the liver, pancreas, and soft tissue

21 January 2018

1 reference

Drinking water chlorination and cancer-a historical cohort study in Finland

21 January 2018

1 reference

Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in the rat.

21 January 2018

1 reference

Ames mutagenicity and concentration of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and of its geometric isomer E-2-chloro-3-(dichloromethyl)-4-oxo-butenoic acid in chlorine-treated tap waters

21 January 2018

1 reference

Structure-activity relationships of bacterial mutagens related to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: an emphasis on the effect of stepwise removal of chlorine from the dichloromethyl group

21 January 2018

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Effect on mutagenicity of the stepwise removal of hydroxyl group and chlorine atoms from 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: 13C NMR chemical shifts as determinants of mutagenicity.

21 January 2018

1 reference

Associations of the bacterial mutagenicity of halogenated 2(5H)-furanones with their MNDO-PM3 computed properties and mode of reactivity with sodium borohydride

21 January 2018

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Bromine-, chlorine-, and mixed halogen-substituted 4-methyl-2(5H)-furanones: synthesis and mutagenic effects of halogen and hydroxyl group replacements.

21 January 2018

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Identification of adenine adducts formed in reaction of calf thymus DNA with mutagenic chlorohydroxyfuranones found in drinking water.

21 January 2018

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Induction of mutation, sister-chromatid exchanges, and chromosome aberrations by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in Chinese hamster ovary cells

21 January 2018

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DNA damage induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in HL-60 cells and purified DNA in vitro

21 January 2018

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Apoptosis in HL-60 cells induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX).

21 January 2018

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3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) induces gene mutations and inhibits metabolic cooperation in cultured Chinese hamster cells

21 January 2018

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Mutagenic and clastogenic properties of 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone: a potent bacterial mutagen in drinking water

21 January 2018

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Identification of adducts formed in reaction of adenosine with 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone, a bacterial mutagen present in chloride disinfected drinking water

21 January 2018

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Reaction of the potent bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) with 2'-deoxyadenosine and calf thymus DNA: identification of fluorescent propenoformyl derivatives

21 January 2018

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Identification of an ethenoformyl adduct formed in the reaction of the potent bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone with guanosine

21 January 2018

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Identification of adducts formed in reactions of 2-deoxyadenosine and calf thymus DNA with the bacterial mutagen 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone

21 January 2018

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Salmonella and mammalian-cell mutagenicity of 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone.

21 January 2018

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Detection of in vivo genotoxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) by the alkaline single cell gel electrophoresis (Comet) assay in multiple mouse organs.

21 January 2018

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A simple technique for quantitation of low levels of DNA damage in individual cells

21 January 2018

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Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis

21 January 2018

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Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing

21 January 2018

1 reference

A plausible mechanism for the mutagenic activity (Salmonella typhimurium TA100) of MX compounds: a formation of CG-CG(+)-CG radical cation by one-electron reduction.

21 January 2018

1 reference

On the mutagenicity of MX compounds.

21 January 2018

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Structural and electronic properties of MX compounds related to TA100 mutagenicity. A semi-empirical molecular orbital QSAR study

21 January 2018

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Analysis of mutagens with single cell gel electrophoresis, flow cytometry, and forward mutation assays in an isolated clone of Chinese hamster ovary cells.

21 January 2018

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Effects of DNA repair deficiency on the mutational specificity in the lacZ gene of Escherichia coli.

21 January 2018

1 reference

Drinking water mutagenicity and gastrointestinal and urinary tract cancers: an ecological study in Finland

21 January 2018

1 reference

Genotoxic activity of chlorohydroxyfuranones in the microscale micronucleus test on mouse lymphoma cells and the unscheduled DNA synthesis assay in rat hepatocytes

21 January 2018

1 reference

Induction of DNA strand breaks by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and humic substances in relation to glutathione and calcium status in human white blood cells

21 January 2018

1 reference

Production of unscheduled DNA synthesis in rodent hepatocytes in vitro, but not in vivo, by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX)

21 January 2018

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Cytogenetic effects in the peripheral lymphocytes and kidney cells of rats exposed to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) orally on three consecutive days

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/EM.10025

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27 November 2017

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