(Q43860570)
English
An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subje
scientific article published on 16 December 2008
Statements
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An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subje (English)
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George R Tonn
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Simon G Wong
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Sylvia C Wong
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Michael G Johnson
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Ji Ma
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Robert Cho
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Leslie C Floren
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Kathryn Kersey
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Karen Berry
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Andrew P Marcus
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Xuemei Wang
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Bettina Van Lengerich
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Julio C Medina
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Paul G Pearson
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Bradley K Wong
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16 December 2008
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37
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3
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502-513
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Identifiers
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