(Q43867610)

27 November 2017

title

Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq. (English)

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phospholipase D-activating G protein-coupled receptor signaling pathway

27 November 2017

main subject

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Gene Ontology release 2020-05-02

Zhi Xie

1

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27 November 2017

Wan-Ting Ho

2

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27 November 2017

Rachel Spellman

3

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27 November 2017

Songmin Cai

4

1 reference

27 November 2017

John H Exton

5

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27 November 2017

language of work or name

English

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publication date

25 January 2002

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Journal of Biological Chemistry

27 November 2017

published in

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27 November 2017

volume

277

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27 November 2017

issue

14

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27 November 2017

page(s)

11979-11986

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Phospholipase D: molecular and cell biology of a novel gene family

27 November 2017

cites work

1 reference

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21 January 2018

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Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins

21 January 2018

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The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling

21 January 2018

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Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

21 January 2018

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Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

21 January 2018

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Cloning and expression analysis of murine phospholipase D1.

21 January 2018

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Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA

21 January 2018

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Functional association between Arf and RalA in active phospholipase D complex

21 January 2018

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Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain

21 January 2018

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Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

21 January 2018

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Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

21 January 2018

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PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation

21 January 2018

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Localization and possible functions of phospholipase D isozymes

21 January 2018

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Structure and regulation of phospholipase D.

21 January 2018

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A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues

21 January 2018

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A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins

21 January 2018

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Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

21 January 2018

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Association of N- and C-terminal domains of phospholipase D is required for catalytic activity

21 January 2018

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The C terminus of mammalian phospholipase D is required for catalytic activity

21 January 2018

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Definition of the protein kinase C interaction site of phospholipase D.

21 January 2018

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Structural analysis of human phospholipase D1.

21 January 2018

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Determination of interaction sites of phospholipase D1 for RhoA

21 January 2018

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Requirements and effects of palmitoylation of rat PLD1.

21 January 2018

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The alpha-subunit of the heterotrimeric G protein G13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases

21 January 2018

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The role of Rho in G protein-coupled receptor signal transduction

21 January 2018

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G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways

21 January 2018

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The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

21 January 2018

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Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13

21 January 2018

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

21 January 2018

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Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways

21 January 2018

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Physical and functional interactions of Galphaq with Rho and its exchange factors

21 January 2018

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Regulation of human PLD1 and PLD2 by calcium and protein kinase C.

21 January 2018

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Phospholipase D activation in fibroblast membranes by the alpha and beta isoforms of protein kinase C.

21 January 2018

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Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity.

21 January 2018

1 reference

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Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts

21 January 2018

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Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c

21 January 2018

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Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites

21 January 2018

1 reference

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Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

21 January 2018

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Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner

21 January 2018

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Actin directly interacts with phospholipase D, inhibiting its activity

21 January 2018

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Inhibition of phospholipase D by amphiphysins

21 January 2018

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Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate.

21 January 2018

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Inhibition of phospholipase D activity by fodrin. An active role for the cytoskeleton.

21 January 2018

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Rho GTPases: signaling, migration, and invasion

21 January 2018

1 reference

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Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase Cγ and protein kinase Cα signalling cascade

21 January 2018

1 reference

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Phospholipase D1 Is Phosphorylated and Activated by Protein Kinase C in Caveolin-enriched Microdomains within the Plasma Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser/Thr phosphorylation of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Conserved amino acids at the C-terminus of rat phospholipase D1 are essential for enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Interaction of the small G protein RhoA with the C terminus of human phospholipase D1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Fatty acylation of phospholipase D1 on cysteine residues 240 and 241 determines localization on intracellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109751200

21 January 2018

Identifiers

DOI

10.1074/JBC.M109751200

1 reference

27 November 2017

1 reference