(Q43882525)

27 November 2017

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells (English)

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27 November 2017

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Xianwu Li

1

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27 November 2017

Li Liu

2

1 reference

27 November 2017

Joan C Tupper

3

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27 November 2017

Douglas D Bannerman

4

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27 November 2017

Robert K Winn

5

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27 November 2017

Said M Sebti

6

1 reference

27 November 2017

Andrew D Hamilton

7

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27 November 2017

John M Harlan

8

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27 November 2017

language of work or name

English

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publication date

11 February 2002

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Journal of Biological Chemistry

27 November 2017

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27 November 2017

277

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27 November 2017

18

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27 November 2017

15309-15316

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Life, death, and the pursuit of apoptosis.

27 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Recent advances in the study of prenylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Involvement of an ICE-like protease in Fas-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Activate NF-kappa B or die?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Endothelial cell survival and apoptosis in the tumor vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Bacterial toxins inhibiting or activating small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

The GTPase Rho has a critical regulatory role in thymus development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Geometric control of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Rho-dependent cell spreading activated by E.coli cytotoxic necrotizing factor 1 hinders apoptosis in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Regulation of intracellular actin polymerization by prenylated cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

New clue to Ras lipid glue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

Akt is more than just a Bad kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201253200

21 January 2018

Identifiers

DOI

10.1074/JBC.M201253200

1 reference

27 November 2017

1 reference