(Q43891600)

27 November 2017

title

Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds (English)

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27 November 2017

Jonathan Z Ho

1

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27 November 2017

Tony S Gibson

series ordinal

2

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27 November 2017

J Edward Semple

series ordinal

3

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27 November 2017

language of work or name

English

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publication date

1 March 2002

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Bioorganic & Medicinal Chemistry Letters

27 November 2017

published in

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27 November 2017

volume

12

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27 November 2017

issue

5

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27 November 2017

page(s)

743-748

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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors

27 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic (2S)-2-amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic acid at P1

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on so

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Thrombin inhibitors based on [5,5] trans-fused indane lactams

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

New advances in the discovery of thrombin and factor Xa inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Asymmetric synthesis of novel quaternary alpha-hydroxy-delta-lactam dipeptide surrogates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Potent and selective thrombin inhibitors featuring hydrophobic, basic P3-P4-aminoalkyllactam moieties

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Exploratory solid-phase synthesis of factor Xa inhibitors: discovery and application of p3-heterocyclic amides as novel types of non-basic arginine surrogates

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Novel benzo-fused lactam scaffolds as factor Xa inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Enhancing paracellular permeability by modulating epithelial tight junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900010-0

7 January 2021

10.1016/S0960-894X(02)00010-0

Identifiers

DOI

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27 November 2017

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