(Q43897866)

English

Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling

scientific article published in January 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

author name string

Axel P Mathieu

1

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Richard J Auchus

2

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Jean Guy LeHoux

3

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

The Journal of Steroid Biochemistry and Molecular Biology

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

80

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

99-107

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

describes a project that uses

site-directed mutagenesis

1 reference

based on heuristic

inferred from title

17 alpha-Hydroxylase/17,20-lyase defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The sequence of the 5'-end of the rat CYP17 gene, the transcription initiation site and a comparison with the homologous genes of other species

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Adrenal glands of mouse and rat do not synthesize androgens

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of C19 steroids on adrenal steroidogenic enzyme activities and their mRNA levels in guinea-pig fasciculata-glomerulosa cells in primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

De novo synthesis of corticosteroids in hamster adrenal glands

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and expression of hamster adrenal cytochrome P450C17 cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunolocalization and biochemical determination of cytochrome P450C17 in adrenals of hamsters treated with ACTH

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A new technique for the assay of infectivity of human adenovirus 5 DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of 17alpha-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined 17 alpha-hydroxylase/17,20-lyase deficiency caused by heterozygous stop codons in the cytochrome P450 17 alpha-hydroxylase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Point mutation of Arg440 to His in cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of proline 409 to arginine in the meander region of cytochrome p450c17 causes severe 17 alpha-hydroxylase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxygen activation by cytochrome P450BM-3: effects of mutating an active site acidic residue.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2801%2900172-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0960-0760(01)00172-8

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

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