(Q43916892)

28 November 2017

title

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice (English)

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28 November 2017

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1

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28 November 2017

Vassilis I Zannis

2

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28 November 2017

publication date

7 December 2005

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Journal of Lipid Research

28 November 2017

published in

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28 November 2017

volume

47

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28 November 2017

issue

3

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28 November 2017

page(s)

521-529

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

28 November 2017

cites work

1 reference

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Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

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Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency

21 January 2018

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The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.

21 January 2018

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Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion

21 January 2018

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Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype

21 January 2018

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Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

21 January 2018

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The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

21 January 2018

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Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.

21 January 2018

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Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.

21 January 2018

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Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia

21 January 2018

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Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

21 January 2018

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Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity

21 January 2018

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Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

21 January 2018

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Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.

21 January 2018

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Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

21 January 2018

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Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

21 January 2018

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Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain

21 January 2018

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Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects

21 January 2018

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Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.

21 January 2018

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The apolipoprotein E2 (Arg145Cys) mutation causes autosomal dominant type III hyperlipoproteinemia with incomplete penetrance

21 January 2018

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Abnormal in vivo metabolism of apolipoprotein E4 in humans

21 January 2018

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Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

21 January 2018

1 reference

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10.1194/JLR.M500322-JLR200

21 January 2018

Identifiers

DOI

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28 November 2017

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