(Q43919085)

English

Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis

scientific article published in March 2002

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scholarly article

1 reference

Europe PubMed Central

28 November 2017

Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis (English)

1 reference

Europe PubMed Central

28 November 2017

prostate carcinoma

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

S Dhanalakshmi

1

1 reference

Europe PubMed Central

28 November 2017

R P Singh

2

1 reference

Europe PubMed Central

28 November 2017

C Agarwal

3

1 reference

Europe PubMed Central

28 November 2017

R Agarwal

4

1 reference

Europe PubMed Central

28 November 2017

language of work or name

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publication date

1 March 2002

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Europe PubMed Central

28 November 2017

1 reference

Europe PubMed Central

28 November 2017

21

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Europe PubMed Central

28 November 2017

11

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Europe PubMed Central

28 November 2017

1759-1767

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Europe PubMed Central

28 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205240

0 references

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Function and activation of NF-kappa B in the immune system

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

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The NF-kappa B and I kappa B proteins: new discoveries and insights

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin

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Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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Genistein inhibits NF-kappa B activation in prostate cancer cells

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.

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NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

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NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

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Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins

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Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

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TNF-induced signaling in apoptosis

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A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

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Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells

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Relationships between proto-oncogene expression and apoptosis induced by anticancer drugs in human prostate tumor cells.

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Oxidative stress, caloric restriction, and aging

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Chemoprevention of cancer

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NF-kappaB activation: the I kappaB kinase revealed?

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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An overview of chemoprevention: current status and future prospects

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Silymarin: a review of its clinical properties in the management of hepatic disorders

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

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Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex

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Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

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Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

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Identifiers

10.1038/SJ.ONC.1205240

1 reference

Europe PubMed Central

28 November 2017

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1 reference

Europe PubMed Central

28 November 2017

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