(Q43940479)

28 November 2017

title

The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability (English)

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28 November 2017

Hyun-Ja Nam

1

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28 November 2017

Sunyoung Chae

2

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28 November 2017

Seung-Hoon Jang

3

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28 November 2017

Hyeseong Cho

4

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28 November 2017

Jae-Ho Lee

5

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28 November 2017

language of work or name

English

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publication date

27 June 2010

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28 November 2017

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28 November 2017

volume

31

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28 November 2017

issue

9

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28 November 2017

page(s)

1531-1540

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The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation

28 November 2017

cites work

1 reference

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

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Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

21 January 2018

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

21 January 2018

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Activating mutations for the met tyrosine kinase receptor in human cancer

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A novel germ line juxtamembrane Met mutation in human gastric cancer

21 January 2018

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

21 January 2018

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Aneuploidy acts both oncogenically and as a tumor suppressor

21 January 2018

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Ras induces chromosome instability and abrogation of the DNA damage response.

21 January 2018

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CIN By WNT: growth pathways, mitotic control and chromosomal instability in cancer

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Centrosome amplification, chromosome instability and cancer development

21 January 2018

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21 January 2018

Chromosomal instability.

1 reference

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Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

1 reference

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Managing the centrosome numbers game: from chaos to stability in cancer cell division

21 January 2018

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Cell cycle kinases in cancer

21 January 2018

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Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

21 January 2018

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Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line.

21 January 2018

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Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail

21 January 2018

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The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

21 January 2018

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The centrosome in normal and transformed cells

21 January 2018

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21 January 2018

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Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression

21 January 2018

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Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis

21 January 2018

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Loss of p53 and centrosome hyperamplification.

21 January 2018

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p53: twenty five years understanding the mechanism of genome protection

21 January 2018

1 reference

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The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

21 January 2018

1 reference

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The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele

21 January 2018

1 reference

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Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

21 January 2018

1 reference

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How to make tubes: signaling by the Met receptor tyrosine kinase

21 January 2018

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PKB/AKT is involved in resumption of meiosis in mouse oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

Two faces of p53: aging and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

Pathway specificity for Met signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGQ133

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGQ133

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28 November 2017

1 reference