(Q43972483)

28 November 2017

title

Co-engagement of CD8 with the T cell receptor is required for negative selection (English)

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28 November 2017

Ingold AL

1

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28 November 2017

Landel C

2

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28 November 2017

Knall C

3

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28 November 2017

Evans GA

4

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28 November 2017

Potter TA

5

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28 November 2017

language of work or name

English

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publication date

1 August 1991

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28 November 2017

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28 November 2017

volume

352

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28 November 2017

issue

6337

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28 November 2017

page(s)

721-723

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Positive and negative selection of T lymphocytes

28 November 2017

cites work

1 reference

7 January 2021

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

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7 January 2021

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1 reference

7 January 2021

Strong xenogeneic HLA response in transgenic mice after introducing an α3 domain into HLA B27

1 reference

7 January 2021

Both TCR/MHC and accessory molecule/MHC interactions are required for positive and negative selection of mature T cells in the thymus

1 reference

7 January 2021

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1 reference

7 January 2021

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

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7 January 2021

T Cell Subsets and the Recognition of MHC Class

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7 January 2021

Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

1 reference

7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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7 January 2021

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

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7 January 2021

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

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7 January 2021

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

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7 January 2021

A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL.

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7 January 2021

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses

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7 January 2021

Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

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7 January 2021

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule

1 reference

7 January 2021

A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

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7 January 2021

The co-receptor function of murine CD4.

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7 January 2021

Regulated expression of a murine class I gene in transgenic mice

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7 January 2021

Identifiers

DOI

10.1038/352721A0

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Dimensions Publication ID

28 November 2017

1034996364

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1 reference