(Q43979139)

28 November 2017

title

One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme (English)

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28 November 2017

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1

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28 November 2017

U Shukla

2

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28 November 2017

S N Hicks

3

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28 November 2017

R D Smiley

4

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28 November 2017

L A Kuhn

5

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28 November 2017

M I Zavodszky

6

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28 November 2017

publication date

1 November 2001

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Journal of Computer - Aided Molecular Design

28 November 2017

published in

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28 November 2017

volume

15

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28 November 2017

issue

11

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28 November 2017

page(s)

1035-1052

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Characterization and stereochemistry of cofactor oxidation by a type II dihydrofolate reductase.

28 November 2017

cites work

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The state of antibody catalysis

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Implications for enzymic catalysis from free-energy reaction coordinate profiles

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Analysis of hydride transfer and cofactor fluorescence decay in mutants of dihydrofolate reductase: possible evidence for participation of enzyme molecular motions in catalysis

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12 December 2020

Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

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12 December 2020

Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein

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12 December 2020

Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble

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12 December 2020

The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity

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12 December 2020

Conformation of NADP+ bound to a type II dihydrofolate reductase.

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12 December 2020

Convergent solutions to binding at a protein-protein interface

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12 December 2020

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

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12 December 2020

Enzyme polarization of substrates of dihydrofolate reductase by different theoretical methods

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12 December 2020

Predicting conserved water-mediated and polar ligand interactions in proteins using a K-nearest-neighbors genetic algorithm.

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12 December 2020

Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase

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12 December 2020

Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

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12 December 2020

Anatomy of hot spots in protein interfaces

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12 December 2020

Mapping the protein universe

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12 December 2020

Conservation of polar residues as hot spots at protein interfaces

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12 December 2020

A geometric approach to macromolecule-ligand interactions

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12 December 2020

Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4

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Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli

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12 December 2020

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task

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Construction of a synthetic gene for an R-plasmid-encoded dihydrofolate reductase and studies on the role of the N-terminus in the protein.

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12 December 2020

Classical electrostatics in biology and chemistry

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

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12 December 2020

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

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12 December 2020

Evolution of enzyme function and the development of catalytic efficiency

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12 December 2020

Theoretical studies on the dihydrofolate reductase mechanism: electronic polarization of bound substrates

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12 December 2020

Database screening for HIV protease ligands: the influence of binding-site conformation and representation on ligand selectivity

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12 December 2020

Emerging principles for the recognition of peptide antigens by MHC class I molecules

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12 December 2020

Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

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12 December 2020

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb

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12 December 2020

Substrate specificity and affinity of a protein modulated by bound water molecules

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12 December 2020

Changes in the electron density of the cofactor NADPH on binding to E. coli dihydrofolate reductase

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12 December 2020

Stretching exercises--flexibility in dihydrofolate reductase catalysis

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12 December 2020

Catalytic promiscuity and the evolution of new enzymatic activities

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12 December 2020

Crystallographic and calorimetric analysis of peptide binding to OppA protein

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12 December 2020

Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.

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12 December 2020

NMR studies of ligand carboxylate group interactions with arginine residues in complexes of Lactobacillus casei dihydrofolate reductase with substrates and substrate analogues

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12 December 2020

Electron redistribution on binding of a substrate to an enzyme: folate and dihydrofolate reductase

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12 December 2020

X-ray crystallographic structures of adipocyte lipid-binding protein complexed with palmitate and hexadecanesulfonic acid. Properties of cavity binding sites

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12 December 2020

Structural and kinetic characterization of a beta-lactamase-inhibitor protein

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12 December 2020

Interligand Overhauser effects in type II dihydrofolate reductase

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12 December 2020

Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor

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12 December 2020

Alpha-pyridine nucleotides as substrates for a plasmid-specified dihydrofolate reductase

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12 December 2020

Protein flexibility predictions using graph theory

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12 December 2020

Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications

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12 December 2020

Chemical basis for enzyme catalysis

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12 December 2020

The molecular surface package

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12 December 2020

Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

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12 December 2020

A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

1 reference

12 December 2020

Matching chemistry and shape in molecular docking

1 reference

12 December 2020

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

12 December 2020

Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

1 reference

12 December 2020

Knowledge-based scoring function to predict protein-ligand interactions.

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1014824725891

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journals/jcamd/HowellSHSKZ01

28 November 2017

DBLP publication ID

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DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

1041206542

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