(Q44038362)

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Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with cytosine deaminase/5-fluorocytosine: preclinical consideration

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scholarly article

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Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Dose of adenoviral vectors expressing interleukin-2 plays an important role in combined gene therapy with cytosine deaminase/5-fluorocytosine: preclinical consideration (English)

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Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

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1 reference

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author name string

Mikihito Nakamori

1

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Makoto Iwahashi

2

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Kentaro Ueda

3

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Takuya Tsunoda

4

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Hiroshi Terasawa

5

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Hirofumi Hamada

6

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Hiroki Yamaue

7

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

publication date

1 June 2002

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Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

number of pages

10

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Japanese Journal of Cancer Research

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Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

93

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

6

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

706-715

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect

1 reference

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Induction of potent antitumor natural killer cell activity by herpes simplex virus-thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer

1 reference

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1 reference

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10 July 2018

Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.

1 reference

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10 July 2018

In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2.

1 reference

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10 July 2018

A family of bicistronic vectors to enhance both local and systemic antitumor effects of HSVtk or cytokine expression in a murine melanoma model

1 reference

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10 July 2018

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

1 reference

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10 July 2018

Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase

1 reference

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10 July 2018

Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo.

1 reference

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10 July 2018

In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine

1 reference

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10 July 2018

Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.

1 reference

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10 July 2018

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

1 reference

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10 July 2018

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome

1 reference

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10 July 2018

The IL-2/IL-2 receptor system: a current overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Lowest dose interleukin-2 immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Detection of wild-type contamination in a recombinant adenoviral preparation by PCR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Cancer vaccines: the interleukin 2 dosage effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Combination gene therapy for liver metastasis of colon carcinoma in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

In VivoAdenovirus-Mediated Gene Transfer of theEscherichia coliCytosine Deaminase Gene to Human Colon Carcinoma-Derived Tumors Induces Chemosensitivity to 5-Fluorocytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

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Adoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Chemosensitivity testing with highly purified fresh human tumour cells with the MTT colorimetric assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

10 July 2018

Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Antitumor effects of interleukin-2 gene-modified fibroblasts in an orthotopic colon cancer model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

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Immune system in suicide-gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Combination gene therapy for oral cancer in a murine model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

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Enhanced interleukin-2 production in human tumor-infiltrating lymphocytes engineered by 3'-truncated interleukin-2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

A simple and efficient method for purification of infectious recombinant adenovirus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

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Cytokine Gene Therapy with Interleukin-2-Transduced Fibroblasts: Effects of IL-2 Dose on Anti-Tumor Immunity

1 reference

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15 August 2018

Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: comparison of adenovirus- and retrovirus-mediated genetic transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5927048

15 August 2018

The immune response elicited by mammary adenocarcinoma cells transduced with interferon-gamma and cytosine deaminase genes cures lung metastases by parental cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12079520

12 December 2020

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Identifiers

10.1111/J.1349-7006.2002.TB01310.X

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 July 2018

http://europepmc.org/abstract/PMC/5927048

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