(Q44051266)

English

Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.

scientific article published in April 2014

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

based on heuristic

inferred from title

Catherine Llorens-Cortès

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

author name string

Fabrice Balavoine

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Michel Azizi

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Damien Bergerot

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Nadia De Mota

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Rémi Patouret

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Bernard P Roques

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

publication date

1 April 2014

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

53

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

4

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

385-395

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337978%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Heart Disease and Stroke Statistics--2013 Update: A Report From the American Heart Association

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

The brain renin-angiotensin system and the development of DOC-salt hypertension

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Angiotensin synthesis in the brain and increased turnover in hypertensive rats

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Aminopeptidase A inhibitors as potential central antihypertensive agents

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Angiotensin III: a central regulator of vasopressin release and blood pressure.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

The role of the brain renin-angiotensin system in hypertension: implications for new treatment.

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Copeptin: clinical use of a new biomarker

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Renin inhibition with aliskiren

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Dual renin-angiotensin system blockade restores blood pressure-renin dependency in individuals with low renin concentrations

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Direct renin inhibition: from pharmacological innovation to novel therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0125-Y

21 January 2018

Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory role of brain angiotensins in the control of physiological and behavioral responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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