(Q44057905)

English

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues

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Europe PubMed Central

PubMed publication ID

29 November 2017

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues (English)

1 reference

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PubMed publication ID

29 November 2017

author name string

Tiffany T Howard

1

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29 November 2017

Brian M Lingerfelt

2

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29 November 2017

Bethany L Purnell

3

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29 November 2017

Adrienne E Scott

4

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29 November 2017

Carly A Price

5

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29 November 2017

Heather M Townes

6

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29 November 2017

LuAnne McNulty

7

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29 November 2017

Heather L Handl

8

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29 November 2017

Kaitlin Summerville

9

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29 November 2017

Stephen J Hudson

10

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29 November 2017

J Phillip Bowen

11

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29 November 2017

Konstantinos Kiakos

12

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29 November 2017

John A Hartley

13

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29 November 2017

Moses Lee

14

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29 November 2017

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publication date

1 September 2002

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29 November 2017

Bioorganic & Medicinal Chemistry

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29 November 2017

10

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29 November 2017

9

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29 November 2017

2941-2952

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29 November 2017

Structure and activity relationship of several novel CC-1065 analogs.

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Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065.

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7 January 2021

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CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents

1 reference

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Comparison of U-73,975 and cisplatin cytotoxicity in fresh cervical and ovarian carcinoma specimens with the ATP-chemosensitivity assay

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Evaluation of the antineoplastic activity of adozelesin alone and in combination with 5-aza-2'-deoxycytidine and cytosine arabinoside on DLD-1 human colon carcinoma cells.

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7 January 2021

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Phase I study of adozelesin administered by 24-hour continuous intravenous infusion

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7 January 2021

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Phase I trial of Adozelesin using the treatment schedule of daily x5 every 3 weeks

1 reference

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7 January 2021

based on heuristic

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Phase I study with the DNA sequence-specific agent adozelesin

1 reference

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7 January 2021

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Myelotoxic effects of the bifunctional alkylating agent bizelesin on human, canine and murine myeloid progenitor cells

1 reference

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Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity

1 reference

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7 January 2021

based on heuristic

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1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

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Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

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Derivatives of methyl 5-methyl-4-oxo-1,2,4,5,8,8a- hexahydrocyclopropa[c]-pyrrolo[3,2-e]indole-7-carboxylate: a case of inverse electronic effects on the reactivity of CC-1065 derivatives

1 reference

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7 January 2021

based on heuristic

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Anticellular and antitumor activity of duocarmycins, novel antitumor antibiotics

1 reference

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7 January 2021

based on heuristic

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Duocarmycins, potent antitumor antibiotics produced by Streptomyces sp. structures and chemistry

1 reference

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7 January 2021

based on heuristic

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Preparation of alkyl-substituted indoles in the benzene portion. Part 15. Asymmetric synthesis of (+)-duocarmycin SA using novel procedure for preparation of hydroxyindoles

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

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Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorus in organic synthesis—VII

1 reference

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7 January 2021

based on heuristic

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Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

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Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

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In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2802%2900157-8

7 January 2021

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Identifiers

10.1016/S0968-0896(02)00157-8

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Europe PubMed Central

PubMed publication ID

29 November 2017

release_3hrnrqyfjnh33oxeavbin4wqcu

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https://api.fatcat.wiki/v0/release/3hrnrqyfjnh33oxeavbin4wqcu

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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