(Q44060474)

29 November 2017

title

(R)-N-[11C]methyl-3-pyrrolidyl benzilate, a high-affinity reversible radioligand for PET studies of the muscarinic acetylcholine receptor (English)

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29 November 2017

Marc B Skaddan

1

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29 November 2017

Doug M Jewett

series ordinal

2

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29 November 2017

Phil S Sherman

series ordinal

3

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29 November 2017

Michael R Kilbourn

series ordinal

4

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29 November 2017

publication date

1 July 2002

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29 November 2017

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29 November 2017

volume

45

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29 November 2017

issue

1

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29 November 2017

page(s)

31-37

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Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases

29 November 2017

cites work

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Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies

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Cortical muscarinic receptor subtypes and Alzheimer's disease

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Synthesis of radiotracers for studying muscarinic cholinergic receptors in the living human brain using positron emission tomography: [11C]dexetimide and [11C]levetimide

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Vesicular acetylcholine transporter density and Alzheimer's disease

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Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease

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In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB.

21 January 2018

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Simplified methods for in vivo measurement of acetylcholinesterase activity in rodent brain

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[11C]tropanyl benzilate-binding to muscarinic cholinergic receptors: methodology and kinetic modeling alternatives

21 January 2018

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21 January 2018

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21 January 2018

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Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review

21 January 2018

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Studies on muscarinic binding sites in human brain identified with [3H]pirenzepine

21 January 2018

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Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation

21 January 2018

1 reference

Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in [...]

21 January 2018

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SPET imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQNP.

21 January 2018

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Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

21 January 2018

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Autoradiographic distribution of M1, M2, M3, and M4 muscarinic receptor subtypes in Alzheimer's disease

21 January 2018

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Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease

21 January 2018

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Aromatic and amine substituent effects on the apparent lipophilicities of N-[(2-pyrrolidinyl)methyl]-substituted benzamides

21 January 2018

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Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors

21 January 2018

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The role of species-dependent metabolism in the regional brain retention of 18F-labeled muscarinic acetylcholine receptor ligands

21 January 2018

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Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders

21 January 2018

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Evaluation of novel PET ligands (+)N-[11C]methyl-3-piperidyl benzilate ([11C](+)3-MPB) and its stereoisomer [11C](-)3-MPB for muscarinic cholinergic receptors in the conscious monkey brain: a PET study in comparison with

21 January 2018

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A simple synthesis of [11C]methyl triflate

21 January 2018

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Evaluation of stereoisomers of 4-fluoroalkyl analogues of 3-quinuclidinyl benzilate in in vivo competition studies for the M1, M2, and M3 muscarinic receptor subtypes in brain

21 January 2018

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Synthesis, in vivo biodistribution and dosimetry of [11C]N-methylpiperidyl benzilate ([11C]NMPB), a muscarinic acetylcholine receptor antagonist

21 January 2018

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A cholinergic connection between normal aging and senile dementia in the human hippocampus

21 January 2018

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Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3

21 January 2018

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Synthesis, (18)F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors

21 January 2018

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Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist

21 January 2018

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In vivo biodistribution of two [18F]-labelled muscarinic cholinergic receptor ligands: 2-[18F]- and 4-[18F]-fluorodexetimide

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/SYN.10079

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29 November 2017

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