(Q44076961)

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Aromatization of 16alpha-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization

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Europe PubMed Central

PubMed publication ID

29 November 2017

Aromatization of 16alpha-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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author name string

Mitsuteru Numazawa

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Mii Tachibana

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Ayako Mutsumi

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Akiko Yoshimura

4

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Yoshio Osawa

5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

publication date

1 June 2002

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Europe PubMed Central

PubMed publication ID

29 November 2017

The Journal of Steroid Biochemistry and Molecular Biology

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Europe PubMed Central

PubMed publication ID

29 November 2017

81

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

165-172

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Purification of human placental aromatase cytochrome P-450 with monoclonal antibody and its characterization

1 reference

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Preparation of [1,2-3H,4-14C]16 alpha-hydroxyandrostenedione and its use for radiometric determination of human placental aromatase activity

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Mechanism of human placental aromatase: a new active site model

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Aromatase inhibitors: their biochemistry and clinical potential

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Aromatase inhibitors in the treatment of breast cancer

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Cytochrome P-450 and the aromatization of 16alpha-hydroxytestosterone and androstenedione by human placental microsomes

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Aromatization of 15 alpha and 16 alpha hydroxylated androgens in the human placental using [1,2-3H]-substrates

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Evidence for separate sites for aromatisation of androstenedione and 16 alpha-hydroxyandrostenedione in human placental microsomes.

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Inhibition study of human placental aromatase with 3-deoxy- and 6-oxo-steroids using [1 beta-3H]16 alpha-hydroxyandrostenedione as a substrate: a comparison to that using [1 beta-3H]androstenedione

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Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

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Regulation of expression of the genes encoding steroidogenic enzymes

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A radiometric assay method for aromatase activity using [1 beta-3H]16 alpha-hydroxyandrostenedione

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Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

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Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity

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A time-dependent inactivation of aromatase by 19-oxygenated androst-4-ene-3,6,17-triones

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Studies directed toward a mechanistic evaluation of aromatase inhibition by androst-5-ene-7,17-dione. Time-dependent inactivation by the 19-nor and 5 beta, 6 beta-epoxy derivatives

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4-Oxygenated androst-5-en-17-ones and their 7-oxo derivatives as aromatase inhibitors

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Studies of human placental aromatase

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Gas chromatography-mass spectrometric determination of activity of human placental aromatase using 16alpha-hydroxyandrostenedione as a substrate

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Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase

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Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis

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Preparation of an activity-inhibiting monoclonal antibody against human placental aromatase cytochrome P450

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Evidence of the direct aromatization of testosterone and different aromatization sites for testosterone and androstenedione in human placental microsomes.

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Metabolic aspects of the 1 beta-proton and the 19-methyl group of androst-4-ene-3,6,17-trione during aromatization by placental microsomes and inactivation of aromatase

1 reference

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Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active site

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Identifiers

10.1016/S0960-0760(02)00060-2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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