(Q44111679)

English

Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity

scientific article published on 20 August 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Toxoplasma gondii

0 references

author name string

Eric F Johnson

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Wolfgang Hinz

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Chloe E Atreya

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Frank Maley

4

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Karen S Anderson

5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

language of work or name

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publication date

20 August 2002

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Europe PubMed Central

PubMed publication ID

29 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

29 November 2017

277

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

45

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

43126-43136

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Atomic structure of thymidylate synthase: target for rational drug design

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

The catalytic mechanism and structure of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

An alternative flavin-dependent mechanism for thymidylate synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: further evidence that thymidylate synthase is a half-of-the-sites activity enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Complete restoration of activity to inactive mutants of Escherichia coli thymidylate synthase: evidence that E. coli thymidylate synthase is a half-the-sites activity enzyme.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

An electrostatic highway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Electrostatic channeling of substrates between enzyme active sites: comparison of simulation and experiment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Crystalline Dihydropteroylglutamic Acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Use of isosbestic point wavelength shifts to estimate the fraction of a precursor that is converted to a given product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206523200

21 January 2018

Identifiers

10.1074/JBC.M206523200

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

ResearchGate publication ID

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