(Q44184962)

English

Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.

scientific article published on 12 July 2011

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

A M Rabuazzo

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

F Purrello

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

publication date

12 July 2011

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Journal of Endocrinological Investigation

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

35

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

504-510

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

https://scigraph.springernature.com/pub.10.3275/7866

0 references

Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro exhaustion of pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexokinase shift to mitochondria is associated with an increased sensitivity to glucose in rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38-dependent enhancement of cytokine-induced nitric-oxide synthase gene expression by heat shock protein 70

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nitric oxide in obesity-induced beta cell disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of high glucose on insulin secretion by isolated rat islets and purified beta-cells and possible role of glycosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper addition prevents the inhibitory effects of interleukin 1-beta on rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of the insulin‐secreting beta cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation, mitochondrial membrane potential and DNA integrity of spermatozoa in relation to intracellular reactive oxygen species in liquid and frozen-thawed buffalo semen

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure to glibenclamide increases rat beta cells sensitivity to glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipotoxicity in human pancreatic islets and the protective effect of metformin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of NIDDM. A balanced overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial free radical theory of ageing--where do we stand?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Airway epithelial cell inflammatory signalling in cystic fibrosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of mitochondrial ROS production on diabetic vascular complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fast reversibility of glucose-induced desensitization in rat pancreatic islets. Evidence for an involvement of ionic fluxes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids and beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids, lipotoxicity and insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21750398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21750398%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44184962&oldid=2108333857"