(Q44187054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

1

1 reference

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16 January 2020

Gisèle Bonne

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Sarah A Reilly

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Wei Wu

3

1 reference

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16 January 2020

Shinichi Iwata

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Shunichi Homma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Howard J Worman

7

1 reference

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16 January 2020

publication date

8 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

published in

Cardiovascular Research

1 reference

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16 January 2020

volume

93

1 reference

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16 January 2020

issue

2

1 reference

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16 January 2020

page(s)

311-319

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068161%20AND%20SRC:MED&resulttype=core&format=json

Laminopathies and the long strange trip from basic cell biology to therapy

16 January 2020

cites work

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Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

21 January 2018

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Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease

21 January 2018

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Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)

21 January 2018

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Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy

21 January 2018

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Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease

21 January 2018

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Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death?

21 January 2018

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Mouse models of the laminopathies.

21 January 2018

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Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

21 January 2018

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Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.

21 January 2018

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Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene

21 January 2018

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From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

21 January 2018

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Pharmacokinetics and pharmacodynamics of AZD6244 (ARRY-142886) in tumor-bearing nude mice

21 January 2018

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

21 January 2018

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

21 January 2018

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Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers

21 January 2018

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Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma

21 January 2018

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Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions

21 January 2018

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Nonparametric Estimation from Incomplete Observations

21 January 2018

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Long-term safety of sorafenib in advanced renal cell carcinoma: follow-up of patients from phase III TARGET.

21 January 2018

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Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

21 January 2018

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MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation

21 January 2018

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Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

21 January 2018

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Long-Term Outcome and Risk Stratification in Dilated Cardiolaminopathies

21 January 2018

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