(Q44287398)

1 December 2017

title

The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells (English)

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ubiquitin-proteasome system

1 December 2017

main subject

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author name string

Anke Hofmeister-Brix

series ordinal

1

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1 December 2017

Sigurd Lenzen

series ordinal

2

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1 December 2017

Simone Baltrusch

series ordinal

3

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1 December 2017

language of work or name

English

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publication date

1 December 2013

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1 December 2017

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1 December 2017

volume

456

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1 December 2017

issue

2

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1 December 2017

page(s)

173-184

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

1 December 2017

1 reference

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Signal recognition by pancreatic B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Association with nitric oxide synthase on insulin secretory granules regulates glucokinase protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Global protein stability profiling in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Generation of destabilized green fluorescent protein as a transcription reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

A critical re-evaluation of CD24-positivity of human embryonic stem cells differentiated into pancreatic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Tissue-specific regulation of glucokinase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Conformational transition pathway in the allosteric process of human glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Proteasome inhibitors: from research tools to drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Hassles with taking out the garbage: aggravating aggresomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130262

21 January 2018

Identifiers

DOI

10.1042/BJ20130262

1 reference

1 December 2017

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