(Q44297785)

1 December 2017

title

A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung (English)

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1 December 2017

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Gy A Csanády

1

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1 December 2017

W Kessler

series ordinal

2

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1 December 2017

H D Hoffmann

series ordinal

3

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1 December 2017

J G Filser

series ordinal

4

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1 December 2017

publication date

1 February 2003

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1 December 2017

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1 December 2017

volume

138

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1 December 2017

issue

1-2

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1 December 2017

page(s)

75-102

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Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

1 December 2017

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7 January 2021

Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation

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7 January 2021

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7 January 2021

Physiological parameter values for physiologically based pharmacokinetic models

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7 January 2021

Blood styrene concentrations in a "normal" population and in exposed workers 16 hours after the end of the workshift

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7 January 2021

Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung

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7 January 2021

Monitoring occupational exposure to styrene from hemoglobin adducts and metabolites in blood

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7 January 2021

A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene

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7 January 2021

Long-term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague-Dawley rats, and para-methylstyrene administered by ingestion in Sprague-Dawley rats and Swiss

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7 January 2021

Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks

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7 January 2021

A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: formation of 2-hydroxyethyl adducts with hemoglobin and DNA.

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7 January 2021

The relevance of physical activity for the kinetics of inhaled gaseous substances.

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7 January 2021

Human styrene exposure. V. Development of a model for biological monitoring.

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7 January 2021

The research background for risk assessment of ethylene oxide: aspects of dose.

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7 January 2021

Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats.

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7 January 2021

Styrene exposure. An experimental study of pulmonary absorption and excretion (author's transl)

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7 January 2021

Species-specific pharmacokinetics of styrene in rat and mouse

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7 January 2021

Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air.

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7 January 2021

A physiologically based simulation approach for determining metabolic constants from gas uptake data

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7 January 2021

Morphometric estimation of pulmonary diffusion capacity. 3. The effect of increased oxygen consumption in Japanese Waltzing mice

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7 January 2021

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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7 January 2021

Blood flow rates through adipose tissues of unanesthetized rats

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7 January 2021

Blood flow to brown adipose tissue and norepinephrine- induced calorigenesis in physically trained rats

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7 January 2021

Styrene oxide in blood, hemoglobin adducts, and urinary metabolites in human volunteers exposed to (13)C(8)-styrene vapors

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7 January 2021

Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation

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7 January 2021

A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation.

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7 January 2021

Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats

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7 January 2021

Styrene-7,8-oxide in blood of workers exposed to styrene

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7 January 2021

Specific DNA adducts induced by some mono-substituted epoxides in vitro and in vivo

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7 January 2021

Regional blood flow in conscious resting rats determined by microsphere distribution

1 reference

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7 January 2021

A model for estimating the daily dietary intake of a substance from food-contact articles: styrene from polystyrene food-contact polymers

1 reference

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7 January 2021

In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human

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7 January 2021

Styrene inhalation toxicity studies in mice. II. Sex differences in susceptibility of B6C3F1 mice

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7 January 2021

Comparison of styrene hepatotoxicity in B6C3F1 and Swiss mice.

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7 January 2021

Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450

1 reference

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7 January 2021

Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts

1 reference

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7 January 2021

Ring test for the determination of N-terminal valine adducts of styrene 7,8-oxide with haemoglobin by the modified Edman degradation technique

1 reference

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7 January 2021

Comparison of ethylene, propylene and styrene 7,8-oxide in vitro adduct formation on N-terminal valine in human haemoglobin and on N-7-guanine in human DNA.

1 reference

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7 January 2021

Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene.

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7 January 2021

Apparent rates of glutathione turnover in rat tissues

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7 January 2021

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.

1 reference

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7 January 2021

Application of Raney nickel to measure adducts of styrene oxide with hemoglobin and albumin

1 reference

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7 January 2021

A pharmacodynamically responsive model of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) transfer between liver and fat at low and high doses.

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7 January 2021

99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours

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7 January 2021

Reaction products in hemoglobin and DNA after in vitro treatment with ethylene oxide and N-(2-hydroxyethyl)-N-nitrosourea.

1 reference

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7 January 2021

In vivo tissue dosimetry as a basis for cross-species extrapolation in cancer risk assessment of propylene oxide.

1 reference

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7 January 2021

Tissue distribution of DNA adducts in male Fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl)guanine by 32P-postlabelling

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Urinary mandelic acid and hemoglobin adducts in fiberglass-reinforced plastics workers exposed to styrene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Estimation of human exposure to styrene and ethylbenzene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Exposure to styrene. Uptake, distribution, metabolism and elimination in man

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Quantitative analysis of styrene monomer in polystyrene and foods including some preliminary studies of the uptake and pharmacodynamics of the monomer in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

Comparison of styrene-7,8-oxide adducts formed via reaction with cysteine, N-terminal valine and carboxylic acid residues in human, mouse and rat hemoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900409-5

7 January 2021

10.1016/S0378-4274(02)00409-5

Identifiers

DOI

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1 December 2017

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