(Q44301645)

1 December 2017

title

1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains (English)

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1 December 2017

author name string

Christopher A Willoughby

1

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1 December 2017

Keith G Rosauer

2

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1 December 2017

Jeffery J Hale

3

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1 December 2017

Richard J Budhu

4

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1 December 2017

Sander G Mills

5

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1 December 2017

Kevin T Chapman

6

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1 December 2017

Malcolm MacCoss

7

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1 December 2017

Lorraine Malkowitz

8

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1 December 2017

Martin S Springer

9

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1 December 2017

Sandra L Gould

10

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1 December 2017

Julie A DeMartino

11

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1 December 2017

Salvatore J Siciliano

12

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1 December 2017

Margaret A Cascieri

13

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1 December 2017

Anthony Carella

14

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1 December 2017

Gwen Carver

15

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1 December 2017

Karen Holmes

16

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1 December 2017

William A Schleif

17

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1 December 2017

Renee Danzeisen

18

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1 December 2017

Daria Hazuda

19

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1 December 2017

Joseph Kessler

20

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1 December 2017

Janet Lineberger

21

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1 December 2017

Michael Miller

22

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1 December 2017

Emilio A Emini

23

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1 December 2017

language of work or name

English

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publication date

1 February 2003

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1 December 2017

number of pages

5

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Bioorganic & Medicinal Chemistry Letters

inferred from page(s)

published in

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1 December 2017

volume

13

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1 December 2017

issue

3

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1 December 2017

page(s)

427-431

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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 December 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Identification of a major co-receptor for primary isolates of HIV-1

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Host factors and the pathogenesis of HIV-induced disease

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Combinatorial synthesis of CCR5 antagonists

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

The Synthesis of Aminopyridines: A Method Employing Palladium-Catalyzed Carbon-Nitrogen Bond Formation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

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https://api.crossref.org/works/10.1016%2FS0960-894X%2802%2900988-5

7 January 2021

10.1016/S0960-894X(02)00988-5

Identifiers

DOI

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1 December 2017

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