(Q44307951)

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Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway

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Europe PubMed Central

PubMed publication ID

1 December 2017

Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

author name string

Robert M Bell

1

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

Derek M Yellon

2

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Europe PubMed Central

PubMed publication ID

1 December 2017

language of work or name

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publication date

1 February 2003

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Europe PubMed Central

PubMed publication ID

1 December 2017

Journal of the American College of Cardiology

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Europe PubMed Central

PubMed publication ID

1 December 2017

41

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Europe PubMed Central

PubMed publication ID

1 December 2017

3

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Europe PubMed Central

PubMed publication ID

1 December 2017

508-515

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Europe PubMed Central

PubMed publication ID

1 December 2017

Reperfusion-induced injury: A possible role for oxidant stress and its manipulation

1 reference

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Does reperfusion injury exist in humans?

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Reperfusion injury revisited: is there a role for growth factor signaling in limiting lethal reperfusion injury?

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Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

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Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

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Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1

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Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

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A coronary primary prevention study of Scottish men aged 45-64 years: trial design. The West of Scotland Coronary Prevention Study Group

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Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

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Use of statins in CNS disorders

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Statins, hormones, and women: benefits and drawbacks for atherosclerosis and osteoporosis

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[Regulation of endothelial NO production by Rho GTPase]

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Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

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3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation

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Protective effects of FK409, a novel nitric oxide donor, against postischemic myocardial dysfunction in guinea-pig hearts

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FK409 ameliorates ischemia-reperfusion injury in heart transplantation following 12-hour cold preservation

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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

1 reference

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7 January 2021

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Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts.

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7 January 2021

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Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

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Statins have biphasic effects on angiogenesis

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Nitric oxide as a mediator of delayed pharmacological (A(1) receptor triggered) preconditioning; is eNOS masquerading as iNOS?

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Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids

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Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

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Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts

1 reference

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The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

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Effects of pravastatin in 3260 patients with unstable angina: results from the LIPID study

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Identifiers

10.1016/S0735-1097(02)02816-4

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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