(Q44340761)

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Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations

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scholarly article

1 reference

Europe PubMed Central

2 December 2017

Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations (English)

1 reference

Europe PubMed Central

2 December 2017

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1 reference

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pharmacokinetics

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author name string

J Hasselström

1

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Europe PubMed Central

2 December 2017

J Säwe

2

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Europe PubMed Central

2 December 2017

publication date

1 April 1993

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Europe PubMed Central

2 December 2017

Clinical Pharmacokinetics

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Europe PubMed Central

2 December 2017

24

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Europe PubMed Central

2 December 2017

4

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Europe PubMed Central

2 December 2017

344-354

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Europe PubMed Central

2 December 2017

https://scigraph.springernature.com/pub.10.2165/00003088-199324040-00007

0 references

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

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Enterohepatic circulation of indomethacin and its role in intestinal irritation

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Long lasting respiratory depression induced by morphine-6-glucuronide?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of area under the curve for drugs subject to enterohepatic cycling

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Hepatic circulation during surgical stress and anesthesia with halothane, isoflurane, or fentanyl.

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Morphine-6-glucuronide: effects on ventilation in normal volunteers

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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The central and peripheral influences of opioids on gastrointestinal propulsion

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Urinary excretion of morphine and its metabolites in morphine-dependent subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Kinetics and dynamics of postoperative intravenous morphine in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Disposition of Morphine in Man

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Analgesic Effect of Morphine Glucuronides

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Relative bioavailability of controlled release morphine tablets (MST continus) in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Age-related morphine kinetics

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https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Extrahepatic glucuronidation of morphine in the dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Analgesic activity of morphine-6-glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

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Extrahepatic morphine metabolism in man during the anhepatic phase of orthotopic liver transplantation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

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Steady-state pharmacokinetics of controlled release oral morphine sulphate in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Interpretation of area under the curve measurements for drugs subject to enterohepatic cycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analgesic potency of normorphine in patients with postoperative pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Kinetics of morphine in patients with renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Morphine intoxication in renal failure: the role of morphine-6-glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Enterohepatic circulation of opioid drugs. Is it clinically relevant in the treatment of cancer patients?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Morphine kinetics in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Morphine-3-glucuronide--a potent antagonist of morphine analgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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The influence of blood sample preparation on measured levels of morphine and its major metabolites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Explanation for potency of repeated oral doses of morphine?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral morphine in cancer pain: influences on morphine and metabolite concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine metabolism in cancer patients on increasing oral doses--no evidence for autoinduction or dose-dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and identification of morphine 3- and 6-glucuronides, morphine 3,6-diglucuronide, morphine 3-ethereal sulfate, normorphine, and normorphine 6-glucuronide as morphine metabolites in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of morphine-6-glucuronide and morphine in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous measurement of hepatic arterial and portal venous flows by transit time ultrasonic volume flowmetry

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Physiological disposition of i.v. morphine in sheep.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extrahepatic metabolism of morphine occurs in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enterohepatic circulation of morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

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Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients--a comparison of two oral formulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forensic drug testing for opiates, III. Urinary excretion rates of morphine and codeine following codeine administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/8491060

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-199324040-00007

1 reference

Europe PubMed Central

2 December 2017

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0 references

1 reference

Europe PubMed Central

2 December 2017

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