(Q44346711)

English

The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

scientific article published in September 1997

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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author name string

L S Stone

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

L B MacMillan

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

K F Kitto

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

L E Limbird

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

G L Wilcox

5

1 reference

Europe PubMed Central

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5 November 2019

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publication date

1 September 1997

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Europe PubMed Central

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5 November 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

18

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

7157-7165

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction Between Opiate Subtype and Alpha-2 Adrenergic Agonists in Suppression of Noxiously Evoked Activity of WDR Neurons in the Spinal Dorsal Horn

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological studies of grooming and scratching behavior elicited by spinal substance P and excitatory amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous intrathecal hydromorphone and clonidine for intractable cancer pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Isobolographic Study of Epidural Clonidine and Fentanyl After Cesarean Section

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-adrenoceptors vs. imidazoline receptors: implications for alpha 2-mediated analgesia and other non-cardiovascular therapeutic uses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of synaptic inhibition by noradrenaline acting at alpha 2-adrenoceptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the involvement of the mu but not delta opioid receptor subtype in the synergistic interaction between opioid and alpha 2 adrenergic antinociception in the rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical analysis of drug-drug and site-site interactions with isobolograms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of adrenergic and opioid receptors in Xenopus oocytes: interaction between alpha 2- and beta 2-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by α-adrenergic receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal morphine in mice: a new technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive actions of alpha 2-adrenoceptor agonists in the rat spinal cord: evidence for antinociceptive alpha 2-adrenoceptor subtypes and dissociation of antinociceptive alpha 2-adrenoceptors from cyclic AMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical analysis of drug combinations for synergism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cyclic AMP production by alpha 2-adrenoceptor stimulation in the guinea-pig spinal cord slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of on- and off-cells is related to nociceptive responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology nomenclature of adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9278550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.17-18-07157.1997

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9278550%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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