(Q44367391)

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The alpha 2-adrenoceptor antagonist idazoxan reverses catalepsy induced by haloperidol in rats independent of striatal dopamine release: role of serotonergic mechanisms

scientific article published on 19 March 2003

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Europe PubMed Central

PubMed publication ID

2 December 2017

The alpha 2-adrenoceptor antagonist idazoxan reverses catalepsy induced by haloperidol in rats independent of striatal dopamine release: role of serotonergic mechanisms (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

1 reference

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1 reference

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author name string

Roberto W Invernizzi

1

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Claudio Garavaglia

2

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Europe PubMed Central

PubMed publication ID

2 December 2017

Rosario Samanin

3

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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publication date

19 March 2003

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Europe PubMed Central

PubMed publication ID

2 December 2017

Neuropsychopharmacology

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Europe PubMed Central

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2 December 2017

28

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Europe PubMed Central

PubMed publication ID

2 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

872-879

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

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Behavioral and biochemical interactions of 5,7-dihydroxy-tryptamine with various drugs when administered intracisternally to adult and developing rats

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The pharmacology of RS-15385-197, a potent and selective alpha 2-adrenoceptor antagonist

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Alpha 1- and alpha 2-adrenoreceptor antagonists differentially influence locomotor and stereotyped behaviour induced by d-amphetamine and apomorphine in the rat.

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Studies on RX 781094: a selective, potent and specific antagonist of α2-adrenoceptors

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Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

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Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function

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Idazoxan treatment in progressive supranuclear palsy

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Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys

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The alpha2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson's disease

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Idazoxan preferentially increases dopamine output in the rat medial prefrontal cortex at the nerve terminal level

1 reference

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The effect of serotonergic agents on haloperidol-induced catalepsy

1 reference

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Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats

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8-Hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis

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The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat

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Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

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The alpha 2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo

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21 January 2018

8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release

1 reference

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Effects of idazoxan on dopamine release in the prefrontal cortex of freely moving rats

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Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals

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Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats by alpha 1 as compared to alpha 2 agonists and antagonists

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Fluoxetine increases extracellular dopamine in the prefrontal cortex by a mechanism not dependent on serotonin: a comparison with citalopram

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Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease

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Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist

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Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

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Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors

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Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

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Dopamine increase in the prefrontal cortex correlates with reversal of haloperidol-induced catalepsy in rats

1 reference

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21 January 2018

Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat.

1 reference

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21 January 2018

Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats

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Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis

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Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: a comparison between the effects produced by pre- and post-synaptic inhibition of dopaminergic neurotransmission

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7 January 2021

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On the central noradrenergic mechanism involved in haloperidol-induced catalepsy in the rat

1 reference

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Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey

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Quinolinic acid lesions of rat striatum abolish D1- and D2-dopamine receptor-mediated catalepsy

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Serotonergic involvement with neuroleptic catalepsy

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A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

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Putting the 'A' in atypical: does α2-adrenoceptor antagonism account for the therapeutic advantage of new antipsychotics?

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Identifiers

10.1038/SJ.NPP.1300119

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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