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Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells.
scientific article published in August 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
title
Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
main subject
pancreas
0 references
author
Luan Wen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Yu Wang
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
author name string
Yong Yang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Aimin Xu
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Donghai Wu
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Yonglong Chen
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
publication date
1 August 2010
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
published in
Developmental Dynamics
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
volume
239
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
issue
8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
page(s)
2198-2207
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
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Crossref
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21 January 2018
Pancreatic protein disulfide isomerase (XPDIp) is an early marker for the exocrine lineage of the developing pancreas in Xenopus laevis embryos.
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7 January 2021
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Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue
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7 January 2021
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GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
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Crossref
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7 January 2021
based on heuristic
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Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.
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7 January 2021
based on heuristic
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Development of the gut in Xenopus laevis
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7 January 2021
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Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression
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Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
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7 January 2021
based on heuristic
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Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
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Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
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Crossref
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https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
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XsFRP5 modulates endodermal organogenesis in Xenopus laevis.
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
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Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
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Crossref
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7 January 2021
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Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases
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Regulation of pancreas plasticity and malignant transformation by Akt signaling.
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A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway
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7 January 2021
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Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death during Xenopus development: a spatio-temporal analysis.
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
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Expression of amylase and other pancreatic genes in Xenopus.
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental conversion of liver to pancreas
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
inferred from DOI database lookup
The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
inferred from DOI database lookup
Development of the pancreas in Xenopus laevis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mediation of the DCC apoptotic signal by DIP13 alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AKT/PKB signaling: navigating downstream
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pancreas and beta-cell development: from the actual to the possible
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-catenin is essential for pancreatic acinar but not islet development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Xenopus pancreas development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-cell-autonomous retinoid signaling is crucial for renal development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wnt/beta-catenin signaling is required for development of the exocrine pancreas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDVDY.22356
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/DVDY.22356
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PubMed publication ID
20568240
1 reference
stated in
Europe PubMed Central
PubMed publication ID
20568240
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20568240%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
ResearchGate publication ID
44692681
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