(Q44424816)

English

Biaryl Analogues of Conformationally Constrained Tricyclic Tropanes as Potent and Selective Norepinephrine Reuptake Inhibitors: Synthesis and Evaluation of Their Uptake Inhibition at Monoamine Transporter Sites

scientific article published on May 8, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 December 2017

Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites (English)

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2 December 2017

Biaryl Analogues of Conformationally Constrained Tricyclic Tropanes as Potent and Selective Norepinephrine Reuptake Inhibitors: Synthesis and Evaluation of Their Uptake Inhibition at Monoamine Transporter Sites (English)

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10.1021/JM020596W

https://api.crossref.org/works/10.1021/JM020596W

29 December 2023

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29 December 2023

molecular medicine

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29 December 2023

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Jia Zhou

1

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2 December 2017

Ao Zhang

2

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2 December 2017

Thomas Kläss

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Europe PubMed Central

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2 December 2017

Yan Ping Ye

6

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Europe PubMed Central

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2 December 2017

Kenneth M. Johnson

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12723962

29 December 2023

Cheng Z. Wang

5

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29 December 2023

Alan P. Kozikowski

7

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Europe PubMed Central

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29 December 2023

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1 May 2003

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2 December 2017

8 May 2003

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12723962

29 December 2023

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/jm020596w

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10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

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2 December 2017

46

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10

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2 December 2017

1997-2007

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2 December 2017

4

13

author name string

Swan N

publication date

1998

1 reference

10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

5

42

2736

author name string

Carroll F. I.

publication date

1999

1 reference

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29 December 2023

Addiction and withdrawal--current views

7

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29 December 2023

The dopamine hypothesis of reward: past and current status

8

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29 December 2023

Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine

9

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29 December 2023

Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects

11

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29 December 2023

Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

12

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29 December 2023

Journal of Pharmacology and Experimental Therapeutics

13

274

1424

author name string

Callahan P. M.

publication date

1995

1 reference

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29 December 2023

Journal of Pharmacology and Experimental Therapeutics

14

297

363

author name string

McMahon L. R.

publication date

2001

1 reference

10.1021/JM020596W

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29 December 2023

Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists.

15

1 reference

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29 December 2023

Modification of behavioral effects of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys.

16

1 reference

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29 December 2023

Serotonergic modulation of the discriminative-stimulus effects of cocaine in squirrel monkeys.

17

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29 December 2023

Phentermine and Fenfluramine: Preclinical Studies in Animal Models of Cocaine Addiction

18

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29 December 2023

FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder

19

1 reference

10.1021/JM020596W

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29 December 2023

Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms

22

1 reference

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29 December 2023

Journal of Pharmacology and Experimental Therapeutics

23

author name string

Kozikowski A. P.

publication date

2003

1 reference

10.1021/JM020596W

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29 December 2023

Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist".

24

1 reference

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29 December 2023

Bioorganic & Medicinal Chemistry Letters

25

3

1332

author name string

Kozikowski A. P.

publication date

1993

1 reference

10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

26

38

3093

author name string

Kozikowski A. P.

publication date

1995

1 reference

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29 December 2023

Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors

27

1 reference

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29 December 2023

Journal of the American Chemical Society

28

120

9073

author name string

Smith M. P.

publication date

1998

1 reference

10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

29

43

360

author name string

Wang S.

publication date

2000

1 reference

10.1021/JM020596W

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29 December 2023

Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors

30

1 reference

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29 December 2023

Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects.

31

1 reference

10.1021/JM020596W

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29 December 2023

Dipolar Cycloaddition Route to Diverse Analogues of Cocaine: The 6- and 7-Substituted 3-Phenyltropanes

32

1 reference

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29 December 2023

Journal of Medicinal Chemistry

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41

1969

author name string

Kozikowski A. P.

publication date

1998

1 reference

10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

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41

4982

author name string

Kozikowski A. P.

publication date

1998

1 reference

10.1021/JM020596W

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29 December 2023

Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles

35

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29 December 2023

SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement

36

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29 December 2023

A novel class of calcium-entry blockers: the 1[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines

37

1 reference

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29 December 2023

Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter

38

1 reference

10.1021/JM020596W

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29 December 2023

Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes

39

1 reference

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29 December 2023

Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.

40

1 reference

10.1021/JM020596W

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29 December 2023

Journal of Medicinal Chemistry

41

40

1251

author name string

Chang A.-C.

publication date

1997

1 reference

10.1021/JM020596W

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29 December 2023

3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.

43

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29 December 2023

Synthesis and ligand binding of tropane ring analogues of paroxetine

44

1 reference

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29 December 2023

Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter

45

1 reference

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29 December 2023

Journal of Medicinal Chemistry

46

37

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author name string

Davies H. M. L.

publication date

1994

1 reference

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29 December 2023

Journal of Medicinal Chemistry

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39

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Davies H. M. L.

publication date

1996

1 reference

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29 December 2023

Journal of Medicinal Chemistry

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Davies H. M. L.

publication date

2001

1 reference

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29 December 2023

The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites

49

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29 December 2023

Synthesis, Cocaine Receptor Affinity, and Dopamine Uptake Inhibition of Several New 2.beta.-Substituted 3.beta.-Phenyltropanes

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29 December 2023

Journal of Medicinal Chemistry

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39

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Chen Z.

publication date

1996

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29 December 2023

Journal of Medicinal Chemistry

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publication date

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Journal of Medicinal Chemistry

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Zhang C.

publication date

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29 December 2023

Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives

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29 December 2023

Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors

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29 December 2023

3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile

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29 December 2023

Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective co

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29 December 2023

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

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29 December 2023

Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters

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29 December 2023

Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters

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29 December 2023

Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.

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Journal of Medicinal Chemistry

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29 December 2023

Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity

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29 December 2023

Chemistry, design, and structure-activity relationship of cocaine antagonists

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29 December 2023

Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter

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29 December 2023

Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin t

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Bioorganic & Medicinal Chemistry Letters

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Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression

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Biological Psychiatry

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29 December 2023

Enhancement of human cortico-motoneuronal excitability by the selective norepinephrine reuptake inhibitor reboxetine.

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Effects of reboxetine, a selective norepinephrine reuptake inhibitor, on sympathetic and parasympathetic outflow to the heart: preliminary data

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Reboxetine, a selective norepinephrine reuptake inhibitor, is an effective and well-tolerated treatment for panic disorder

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Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine

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Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists

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Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters

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Journal of Medicinal Chemistry

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29 December 2023

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10.1021/JM020596W

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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