(Q44439310)

English

Lipopolysaccharide and Cecal Ligation/Puncture Differentially Affect the Subcellular Distribution of the Pregnane X Receptor but Consistently Cause Suppression of Its Target Genes CYP3A

scientific article published on May 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Lipopolysaccharide and Cecal Ligation/Puncture Differentially Affect the Subcellular Distribution of the Pregnane X Receptor but Consistently Cause Suppression of Its Target Genes CYP3A (English)

1 reference

10.1097/01.SHK.0000048903.46342.EC

https://api.crossref.org/works/10.1097/01.SHK.0000048903.46342.EC

1 January 2024

lipopolysaccharide

1 reference

based on heuristic

inferred from title

emergency medicine

1 reference

10.1097/01.SHK.0000048903.46342.EC

https://api.crossref.org/works/10.1097/01.SHK.0000048903.46342.EC

1 January 2024

author name string

Karuna Sachdeva

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Bingfang Yan

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Clinton O. Chichester

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744492

1 January 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12744492

1 January 2024

publication date

1 May 2003

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

full work available at URL

https://journals.lww.com/10.1097/01.shk.0000048903.46342.ec

1 reference

10.1097/01.SHK.0000048903.46342.EC

https://api.crossref.org/works/10.1097/01.SHK.0000048903.46342.EC

1 January 2024

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

19

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Europe PubMed Central

PubMed publication ID

3 December 2017

5

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Europe PubMed Central

PubMed publication ID

3 December 2017

469-474

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

A shock toxin that produces disseminated intravascular coagulation and multiple organ failure

1

1 reference

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Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia.

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Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture

4

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Current clinical topics in infectious diseases

5

21

148

author name string

Llewelyn

publication date

2001

1 reference

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Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture

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Alteration of drug biotransformation and elimination during infection and inflammation

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Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response

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Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide

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Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

14

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

15

1 reference

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Regulation of cyp3a gene transcription by the pregnane x receptor

16

1 reference

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

17

1 reference

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

18

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Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

19

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Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

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Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

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Drug Metabolism and Disposition

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186

author name string

Zhu

publication date

2000

1 reference

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Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B).

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Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation

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Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

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The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat

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Induction of the CYP4A subfamily by perfluorodecanoic acid: the rat and the guinea pig as susceptible and non-susceptible species

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry.

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Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

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Ligands have various potential effects on the degradation of pregnane X receptor by proteasome

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Identifiers

10.1097/01.SHK.0000048903.46342.EC

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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