(Q44440512)

English

Glucosamine Induces Resistance to Insulin-Like Growth Factor I (IGF-I) and Insulin in Hep G2 Cell Cultures: Biological Significance of IGF-I/Insulin Hybrid Receptors

scientific article published on June 1, 2003

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors (English)

1 reference

Europe PubMed Central

3 December 2017

Glucosamine Induces Resistance to Insulin-Like Growth Factor I (IGF-I) and Insulin in Hep G2 Cell Cultures: Biological Significance of IGF-I/Insulin Hybrid Receptors (English)

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

1 reference

based on heuristic

inferred from title

0 references

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

author name string

K. Sakai

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12746299

2 January 2024

D. R. Clemmons

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12746299

2 January 2024

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publication date

1 June 2003

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Europe PubMed Central

3 December 2017

full work available at URL

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Europe PubMed Central

3 December 2017

144

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Europe PubMed Central

3 December 2017

6

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Europe PubMed Central

3 December 2017

2388-2395

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Europe PubMed Central

3 December 2017

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

1

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Intramolecular subunit interactions between insulin and insulin-like growth factor 1 alpha beta half-receptors induced by ligand and Mn/MgATP binding

2

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues

4

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

5

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin-resistant women with gestational hypertension

6

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.

7

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

10

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor

11

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Regulation of glycogen synthase and protein phosphatase-1 by hexosamines

12

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues

13

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment

14

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal

15

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture

16

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Effects of insulin-like growth factors on chick embryo hepatocytes

17

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle

18

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway

19

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

20

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

21

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance

22

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.

23

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

24

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

25

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients

27

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

28

1 reference

10.1210/EN.2002-221133

https://api.crossref.org/works/10.1210/EN.2002-221133

2 January 2024

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10.1210/EN.2002-221133

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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