(Q44457424)
Statements
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement (English)
Ian Churcher
Susie Williams
Sonia Kerrad
Timothy Harrison
José L Castro
Mark S Shearman
Huw D Lewis
Earl E Clarke
Jonathan D J Wrigley
Yui S Tang