(Q44472669)

3 December 2017

title

Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117. (English)

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3 December 2017

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Jagabandhu Das

1

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3 December 2017

James Lin

2

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3 December 2017

Robert V Moquin

3

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3 December 2017

Zhongqi Shen

4

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3 December 2017

Steven H Spergel

5

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3 December 2017

John Wityak

6

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3 December 2017

Arthur M Doweyko

7

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3 December 2017

Henry F DeFex

8

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3 December 2017

Qiong Fang

9

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3 December 2017

Suhong Pang

10

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3 December 2017

Sidney Pitt

11

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3 December 2017

Ding Ren Shen

12

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3 December 2017

Gary L Schieven

13

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3 December 2017

Joel C Barrish

14

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3 December 2017

language of work or name

English

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publication date

1 July 2003

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Bioorganic & Medicinal Chemistry Letters

3 December 2017

published in

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3 December 2017

volume

13

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3 December 2017

issue

13

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3 December 2017

page(s)

2145-2149

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Profound block in thymocyte development in mice lacking p56lck

3 December 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

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https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Role of tyrosine kinases in lymphocyte activation: targets for drug intervention

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2803%2900380-9

7 January 2021

10.1016/S0960-894X(03)00380-9

Identifiers

DOI

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3 December 2017

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