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Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.
scientific article published on 29 May 2017
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Europe PubMed Central
PMC publication ID
5494977
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21 March 2020
title
Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
(English)
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5494977
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21 March 2020
main subject
mechanotransduction
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Jennifer L Bays
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1
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5494977
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21 March 2020
Hannah K Campbell
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2
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5494977
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21 March 2020
Michael Sebbagh
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4
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5494977
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21 March 2020
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Christy Heidema
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3
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5494977
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21 March 2020
Kris A DeMali
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5
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5494977
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21 March 2020
publication date
29 May 2017
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5494977
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21 March 2020
published in
Nature Cell Biology
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5494977
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21 March 2020
volume
19
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5494977
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21 March 2020
issue
6
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Europe PubMed Central
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5494977
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21 March 2020
page(s)
724-731
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Europe PubMed Central
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5494977
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28553939%20AND%20SRC:MED&resulttype=core&format=json
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21 March 2020
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Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions
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Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway
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E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch
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25 May 2018
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.
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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
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Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
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Mechanical tugging force regulates the size of cell-cell junctions
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Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin
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AMP-activated protein kinase regulates the assembly of epithelial tight junctions
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Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava.
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A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein
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Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle
1 reference
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7 January 2021
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10.1038/NCB3537
1 reference
stated in
Europe PubMed Central
PMC publication ID
5494977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28553939%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMC publication ID
5494977
1 reference
stated in
Europe PubMed Central
PMC publication ID
5494977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28553939%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed publication ID
28553939
1 reference
stated in
Europe PubMed Central
PMC publication ID
5494977
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28553939%20AND%20SRC:MED&resulttype=core&format=json
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21 March 2020
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