(Q44577871)

English

Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats

scientific article published in September 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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Akihiro Hagiwara

1

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4 December 2017

Norio Imai

2

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4 December 2017

Yuko Doi

3

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4 December 2017

Kyoko Nabae

4

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4 December 2017

Takeshi Hirota

5

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4 December 2017

Hiroko Yoshino

6

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4 December 2017

Mayumi Kawabe

7

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4 December 2017

Yoko Tsushima

8

1 reference

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4 December 2017

Hiromitsu Aoki

9

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4 December 2017

Kazuo Yasuhara

10

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4 December 2017

Takatoshi Koda

11

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4 December 2017

Mikio Nakamura

12

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4 December 2017

Tomoyuki Shirai

13

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4 December 2017

language of work or name

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publication date

1 September 2003

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4 December 2017

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Europe PubMed Central

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4 December 2017

199

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4 December 2017

1

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4 December 2017

9-17

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4 December 2017

Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice

1 reference

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7 January 2021

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The safety and regulatory status of food, drug and cosmetics colour additives exempt from certification

1 reference

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7 January 2021

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Evaluation of the genotoxicity of some natural food colours using bacterial assays.

1 reference

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7 January 2021

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Evaluation of the developmental toxicity of annatto in the rat.

1 reference

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7 January 2021

based on heuristic

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A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats

1 reference

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7 January 2021

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Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride

1 reference

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7 January 2021

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Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats

1 reference

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7 January 2021

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Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis

1 reference

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7 January 2021

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Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.

1 reference

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7 January 2021

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A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests

1 reference

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7 January 2021

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Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay

1 reference

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7 January 2021

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Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats

1 reference

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7 January 2021

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Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay

1 reference

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7 January 2021

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Correlation between medium-term liver bioassay system data and results of long-term testing in rats

1 reference

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7 January 2021

based on heuristic

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Quantitative evaluation of hepatic foci of cellular alteration occurring spontaneously in Fischer-344 rats

1 reference

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7 January 2021

based on heuristic

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Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens

1 reference

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7 January 2021

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Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine

1 reference

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7 January 2021

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Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens

1 reference

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7 January 2021

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The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated wi

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7 January 2021

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Primary mutagenicity screening of food additives currently used in Japan

1 reference

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7 January 2021

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Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

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In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids.

1 reference

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7 January 2021

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Nitrosation and mutagenicity of some amine drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

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Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Dose-dependent induction of GST-P+ staining foci by the rat hepatocarcinogen methapyrilene in the medium-term bioassay

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

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The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Bixin and norbixin in human plasma: determination and study of the absorption of a single dose of Annatto food color

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2803%2900339-2

7 January 2021

based on heuristic

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Hormesis: a generalizable and unifying hypothesis

1 reference

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7 January 2021

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Applications of hormesis in toxicology, risk assessment and chemotherapeutics

1 reference

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7 January 2021

based on heuristic

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Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.

1 reference

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7 January 2021

based on heuristic

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Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine

1 reference

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7 January 2021

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Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats

1 reference

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Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect

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Identifiers

10.1016/S0304-3835(03)00339-2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

release_wdc7wu4dabhe3pri2kvjjtvuqy

1 reference

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24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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