(Q4459745)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2C9

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2C9

Toll-like receptor 6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y2C9

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

Toll-like receptor 2 binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2017

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9Y2C9

protein binding

3 references

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

lipopeptide binding

Discrimination of bacterial lipoproteins by Toll-like receptor 6

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

amyloid-beta binding

IC

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

transmembrane signaling receptor activity

IC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

signaling receptor binding

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

Toll-like receptor 2 binding

signaling receptor activity

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

identical protein binding

protein heterodimerization activity

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

phagocytic vesicle membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

integral component of plasma membrane

1 reference

9 May 2017

TLR6: A novel member of an expanding toll-like receptor family

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9Y2C9

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

Toll-like receptor 2-Toll-like receptor 6 protein complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

intracellular anatomical structure

1 reference

1 January 2018

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2C9&geneProductId=UniProtKB:Q9Y2C9

receptor complex

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

positive regulation of NLRP3 inflammasome complex assembly

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of JUN kinase activity

1 reference

8 April 2019

TLR6: A novel member of an expanding toll-like receptor family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

cellular response to diacyl bacterial lipopeptide

activation of NF-kappaB-inducing kinase activity

NAS

1 reference

8 April 2019

TLR6: A novel member of an expanding toll-like receptor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

toll-like receptor 6 signaling pathway

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

defense response to bacterium

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

TLR6: A novel member of an expanding toll-like receptor family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

toll-like receptor TLR6:TLR2 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

nitric oxide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

response to bacterial lipoprotein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

microglial cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

toll-like receptor signaling pathway

3 references

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

immune response

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

MyD88-dependent toll-like receptor signaling pathway

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

positive regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

negative regulation of toll-like receptor 2 signaling pathway

1 reference

8 April 2019

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

TRIF-dependent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of nitric oxide biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

cellular response to diacyl bacterial lipopeptide

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

cellular response to oxidised low-density lipoprotein particle stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of cytokine production involved in inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of oxidative stress-induced neuron death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

positive regulation of reactive oxygen species biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9

1 reference

8 April 2019

cellular response to amyloid-beta

1 reference

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2C9