(Q4459747)

http://www.ebi.ac.uk/interpro/protein/Q9NR97

Leucine-rich repeat domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR97

Toll-like receptor 8

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NR97

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

double-stranded RNA binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

transmembrane signaling receptor activity

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

signaling receptor activity

1 reference

8 April 2019

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

pattern recognition receptor activity

NAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

endoplasmic reticulum membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

endolysosome membrane

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

integral component of plasma membrane

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR97&geneProductId=UniProtKB:Q9NR97

external side of plasma membrane

1 reference

8 April 2019

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

regulation of protein phosphorylation

biological process

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

immune system process

1 reference

8 April 2019

1 reference

8 April 2019

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

MyD88-dependent toll-like receptor signaling pathway

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

microglial cell activation

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

cellular response to mechanical stimulus

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

immunoglobulin mediated immune response

IEP

1 reference

8 April 2019

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

toll-like receptor 9 signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

I-kappaB kinase/NF-kappaB signaling

1 reference

27 March 2018

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NR97&geneProductId=UniProtKB:Q9NR97

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

inflammatory response

toll-like receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

positive regulation of interleukin-6 production

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

defense response to virus

3 references

8 April 2019

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR97

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5051

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301618

Gene Atlas image

PBB GE TLR8 220832 at fs.png
732 × 530; 10 KB

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Identifiers

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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28 October 2013

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016