(Q44612499)

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Mildly oxidised LDL induces more macrophage death than moderately oxidised LDL: roles of peroxidation, lipoprotein-associated phospholipase A2 and PPARgamma.

scientific article published in October 2003

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19 December 2019

Mildly oxidised LDL induces more macrophage death than moderately oxidised LDL: roles of peroxidation, lipoprotein-associated phospholipase A2 and PPARgamma (English)

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19 December 2019

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Keri L. Carpenter

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19 December 2019

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Iain R Challis

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19 December 2019

Mark J Arends

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1 October 2003

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19 December 2019

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19 December 2019

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19 December 2019

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19 December 2019

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19 December 2019

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Is vascular smooth muscle cell proliferation beneficial?

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21 January 2018

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man

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Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography.

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21 January 2018

The role of lipid peroxidation and antioxidants in oxidative modification of LDL.

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21 January 2018

Good COP, bad COP: an unsolved murder. Are dietary cholesterol oxidation products guilty of atherogenicity?

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21 January 2018

Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

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21 January 2018

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

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21 January 2018

Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells

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21 January 2018

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

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21 January 2018

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

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21 January 2018

Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro

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21 January 2018

PPARgamma and atherosclerosis: effects on cell growth and movement

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21 January 2018

Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism

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21 January 2018

7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein

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21 January 2018

Toxicity of oxysterols to human monocyte-macrophages.

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21 January 2018

The measurement and mechanism of lipid peroxidation in biological systems

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21 January 2018

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

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21 January 2018

Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme

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21 January 2018

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

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21 January 2018

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

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21 January 2018

Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists

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21 January 2018

Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner

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21 January 2018

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

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21 January 2018

Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.

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21 January 2018

Four deaths and a funeral: from caspases to alternative mechanisms.

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21 January 2018

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

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21 January 2018

Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells

1 reference

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21 January 2018

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition

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21 January 2018

Phospholipids in oxidized LDL not adducted to apoB are recognized by the CD36 scavenger receptor

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21 January 2018

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

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21 January 2018

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

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21 January 2018

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

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7 January 2021

Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995.

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Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development

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Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol

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Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants

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Cell-mediated oxidation of LDL: comparison of different cell types of the atherosclerotic lesion

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Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides

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7 January 2021

Factors affecting events during oxidation of low density lipoprotein: correlation of multiple parameters of oxidation

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7 January 2021

Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2

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7 January 2021

Oxysterols in cap and core of human advanced atherosclerotic lesions

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Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper

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Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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Lipoprotein-Associated Phospholipase A 2 , Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions

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Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase

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Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells

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Identifiers

10.1016/S0014-5793(03)01007-X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14550563%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14550563%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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