(Q44620626)

4 December 2017

Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability (English)

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4 December 2017

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

22 March 2024

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

22 March 2024

author name string

Keith Kirkwood

1

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4 December 2017

Thomas Martin

2

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4 December 2017

Young Joon Kim

4

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4 December 2017

Stelios T. Andreadis

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14563491

22 March 2024

language of work or name

English

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publication date

1 November 2003

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full work available at URL

4 December 2017

https://api.elsevier.com/content/article/PII:S0006295203004507?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

https://api.elsevier.com/content/article/PII:S0006295203004507?httpAccept=text/plain

22 March 2024

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

22 March 2024

published in

Biochemical Pharmacology

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4 December 2017

66

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4 December 2017

9

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4 December 2017

1809-1819

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The role of cytokines and their inhibitors in arthritis

4 December 2017

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Cytokines in rheumatoid arthritis

7 January 2021

1 reference

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Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis

7 January 2021

1 reference

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Leukaemia inhibitory factor stimulates proteoglycan resorption in porcine articular cartilage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Role of cytokines in bone resorption

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone: regulation by interleukin-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

The influence of serum cytokines and growth factors on osteoclast formation in Paget's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Chemically modified tetracyclines inhibit inducible nitric oxide synthase expression and nitric oxide production in cultured rat mesangial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Anti-inflammatory effects of chemically modified tetracyclines by the inhibition of nitric oxide and interleukin-12 synthesis in J774 cell line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Non-antimicrobial and antimicrobial tetracyclines inhibit IL-6 expression in murine osteoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

IL-1 beta increases type 1 inositol trisphosphate receptor expression and IL-6 secretory capacity in osteoblastic cell cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Inositol trisphosphate receptor gene expression and hormonal regulation in osteoblast-like cell lines and primary osteoblastic cell cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Cloning and characterization of the type I inositol 1,4,5-trisphosphate receptor gene promoter. Regulation by 17beta-estradiol in osteoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Biochemical Characterization with Parathormone and Calcitonin of Isolated Bone Cells: Provisional Identification of Osteoclasts and Osteoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Characterization of the transcription products of glyceraldehyde 3-phosphate-dehydrogenase gene in HeLa cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Tetracycline derivative CMT-3 inhibits cytokine production, degranulation, and proliferation in cultured mouse and human mast cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Tetracycline/flurbiprofen combination therapy modulates bone remodeling in ovariectomized rats: preliminary observations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Messenger RNA degradation in eukaryotes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Signal transduction via the MAP kinases: proceed at your own RSK.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

How MAP kinases are regulated

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Inhibition of p38 MAP kinase as a therapeutic strategy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, throughout murine development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Treatment of osteoporosis with MMP inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900450-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Chemically modified non-antimicrobial tetracyclines inhibit activity of phospholipases A2

42

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements

22 March 2024

47

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https://api.crossref.org/works/10.1016/S0006-2952(03)00450-7

22 March 2024

Identifiers

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4 December 2017

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