(Q44624766)

English

Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA

scientific article published on November 10, 2003

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Europe PubMed Central

PubMed publication ID

4 December 2017

Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA (English)

1 reference

10.1016/J.MRGENTOX.2003.08.001

https://api.crossref.org/works/10.1016/J.MRGENTOX.2003.08.001

23 March 2024

author name string

Hiroaki Nii

1

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Europe PubMed Central

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4 December 2017

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publication date

1 November 2003

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Europe PubMed Central

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4 December 2017

10 November 2003

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14568301

23 March 2024

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https://api.elsevier.com/content/article/PII:S1383571803002110?httpAccept=text/xml

1 reference

10.1016/J.MRGENTOX.2003.08.001

https://api.crossref.org/works/10.1016/J.MRGENTOX.2003.08.001

23 March 2024

https://api.elsevier.com/content/article/PII:S1383571803002110?httpAccept=text/plain

1 reference

10.1016/J.MRGENTOX.2003.08.001

https://api.crossref.org/works/10.1016/J.MRGENTOX.2003.08.001

23 March 2024

Mutation Research

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Europe PubMed Central

PubMed publication ID

4 December 2017

541

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Europe PubMed Central

PubMed publication ID

4 December 2017

1-2

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Europe PubMed Central

PubMed publication ID

4 December 2017

123-136

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Europe PubMed Central

PubMed publication ID

4 December 2017

Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics

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Identification of tetrahydro-beta-carboline-3-carboxylic acid in foodstuffs, human urine and human milk

3

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Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods.

4

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Harman and norharman induce SOS responses and frameshift mutations in bacteria.

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Genotoxic potential of beta-carbolines: a review.

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Formation of DNA adducts by the co-mutagen norharman with aromatic amines.

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Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline.

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Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.

9

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Marked differences between mutagenicity in Salmonella and tumour-initiating activities of dibenzo[a,e]fluoranthene proximate metabolites; initiation inhibiting activity of norharman

10

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Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman

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Chronic effects of norharman in rats treated with aniline.

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Interactions of norharman and harman with DNA

13

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Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells

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Enhancing effect of heterocyclic amines and beta-carbolines on UV or chemically induced mutagenesis in E. coli

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23 March 2024

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibits the binding activity of T4 endonuclease V to UV-damaged DNA.

16

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23 March 2024

Comutagenic effect of norharman with aminopyridine derivatives.

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Suppressing effects of S phase post-treatment with carbolines on sister-chromatid exchanges induced by mitomycin C in Chinese hamster cells

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Norharman and ellipticine: a comparison of their albilities to interact with DNA in vitro.

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Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats

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Species differences in the biochemical properties of liver microsomal arylamine and arylamide N-hydroxylases

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Purification and characterization of hepatic aldehyde oxidase in male and female mice.

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Inhibition by norharman of metabolism of benzo[a]pyrene by the microsomal mixed function oxidase of rat liver

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Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17)

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Effects of metyrapone and norharmane on microsomal mono-oxygenase and epoxide hydrolase activities

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32P-postlabeling analysis of inhibition by norharman of formation of dibenzo[a,e]fluoranthene--DNA adducts in mouse embryo fibroblasts

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Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands

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Hepatocarcinogenic activities of hydroxymethyl derivatives of 4-(N,N-dimethylamino)azobenzene in ACI/N rats

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Mutagenicity of N-nitrosobis(2-hydroxypropyl)amine and its related compounds in the presence of rat lung and liver S9.

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Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

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Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions

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Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats.

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The effect of cianidanol on rat hepatic monooxygenase activities

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4-Nitrophenol UDPglucuronyltransferase (rat liver)

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Revised methods for the Salmonella mutagenicity test

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Interaction of bleomycin A2 with deoxyribonucleic acid: DNA unwinding and inhibition of bleomycin-induced DNA breakage by cationic thiazole amides related to bleomycin A2

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Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17)

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The high-affinity binding of [3H]norharman ([3H]beta-carboline) to the ethanol-inducible cytochrome P450 2E1 in rat liver.

44

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Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates

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A simple method for assessment of rat cytochrome P-448 isozymes responsible for the mutagenic activation of carcinogenic chemicals.

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Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats

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Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline

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Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline

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Apparent stimulation of dibenzo[a,e]fluoranthene in vitro metabolism in the presence of norharman

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Effect of cigarette smoke on the mutagenic activation of environmental carcinogens by rodent liver.

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The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets

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[3H]norharman ([3H]beta-carboline) binds reversibly and with high affinity to a specific binding site in rat liver.

76

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Immunological comparison of hepatic and extrahepatic cytochromes P-450

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Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat

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Polymorphisms in xenobiotic conjugation and disease predisposition

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Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk

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10.1016/J.MRGENTOX.2003.08.001

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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